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RPS6KA3 Antibodies
AND RPS6KA3 ELISA kits, RPS6KA3 Proteins
Many biological assays use antibodies to detect RPS6KA3, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with RPS6KA3 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop RPS6KA3 antibodies...
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RPS6KA3 Infographic by Boster Bio
All RPS6KA3 Products
Product
Figures
Specificity
Applications
Price
Human, Mouse, Rat
ELISA, Flow Cytometry, IP, IF, ICC, WB
$370
Cat # A02215-2
100 μg/vial
Cat # A02215-2
100 μg/vial
Human, Mouse, Rat
Flow Cytometry, IHC, WB
$370
Cat # M02215-1
100 μl/vial
Cat # M02215-1
100 μl/vial
RPS6KA3 Overview
Facts about Ribosomal protein S6 kinase alpha-3.
Ribosomal protein S6 kinase alpha-3 (RPS6KA3)
Serine/threonine-protein kinase that acts downstream of ERK (MAPK1/ERK2 and MAPK3/ERK1) signaling and mediates mitogenic and stress-induced activation of the transcription factors CREB1, ETV1/ER81 and NR4A1/NUR77, regulates translation via RPS6 and EIF4B phosphorylation, and mediates cellular proliferation, survival, and differentiation by regulating mTOR signaling and repressing pro-apoptotic role of BAD and DAPK1. In fibroblast, is required for EGF-stimulated phosphorylation of CREB1 and histone H3 in'Ser-10', which results in the following transcriptional activation of numerous immediate-early genes.
In response to mitogenic stimulation (EGF and PMA), phosphorylates and activates NR4A1/NUR77 and ETV1/ER81 transcription factors and the cofactor CREBBP. Upon insulin-derived signal, acts indirectly on the transcription regulation of several genes by phosphorylating GSK3B in'Ser-9' and inhibiting its activity.
Gene Information
| Human | |
|---|---|
| Gene Name: | RPS6KA3 |
| Uniprot: | P51812 |
| Entrez: | 6197 |
Family
| Belongs to: |
|---|
| protein kinase superfamily |
Alternative Names
90 kDa ribosomal protein S6 kinase 3; CLS; Coffin-Lowry syndrome; EC 2.7.11; EC 2.7.11.1; HU-3; Insulin-stimulated protein kinase 1; ISPK1; ISPK-1; MAP kinase-activated protein kinase 1b; MAPK-activated protein kinase 1b; MAPKAP kinase 1b; MAPKAPK1B; MAPKAPK-1b; mental retardation, X-linked 19; MRX19; p90-RSK2; p90RSK3; pp90RSK2; ribosomal protein S6 kinase alpha-3; ribosomal protein S6 kinase, 90kD, polypeptide 3; ribosomal protein S6 kinase, 90kDa, polypeptide 3; Ribosomal S6 kinase 2; RPS6KA3; RSK; RSK2; RSK-2; RSK2p90-RSK 3; S6K-alpha3; S6K-alpha-3
Molecular Weight
Mass (kDA):
83.736 kDA
Genomic Context
| Human | |
|---|---|
| Location: | Xp22.12 |
| Sequence: | X; NC_000023.11 (20149911..20267514, complement) |
Tissue Specificity
Expressed in many tissues, highest levels in skeletal muscle.
Subcellular Localizations
Nucleus. Cytoplasm.
Diseases
- Coffin-lowry Syndrome
- Growth Retardation
- Fragile X Syndrome
- Impaired Cognition
- Malnutrition
- Learning Disabilities
- Hepatitis B
- Carcinoma
- Liver Carcinoma
- Hepatitis
- Muscle Hypotonia
Interacting Proteins
- MAPK1
Pathways
- Translation
- Transport
- Neurogenesis
- Synaptic Transmission
- Localization
- Startle Response
- Adult Behavior
- Reverse Transcription
- Cell Death
PTMs
Research Areas
- Cancer
- Protein Kinase
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/RPS6KA3
bosterbio.com/bosterbio-gene-info-cards/RPS6KA3
References
PMID: 7813820 by Bjoerbaek C., et al. Cloning of a human insulin-stimulated protein kinase (ISPK-1) gene and analysis of coding regions and mRNA levels of the ISPK-1 and the protein phosphatase-1 genes in muscle from NIDDM patients.
PMID: 8141249 by Moller D.E., et al. Human rsk isoforms: cloning and characterization of tissue-specific expression.