RPS6KA3 Antibodies

Ribosomal protein S6 kinase alpha-3 (RPS6KA3)

Serine/threonine-protein kinase that acts downstream of ERK (MAPK1/ERK2 and MAPK3/ERK1) signaling and mediates mitogenic and stress-induced activation of the transcription factors CREB1, ETV1/ER81 and NR4A1/NUR77, regulates translation via RPS6 and EIF4B phosphorylation, and mediates cellular proliferation, survival, and differentiation by regulating mTOR signaling and repressing pro-apoptotic role of BAD and DAPK1. In fibroblast, is required for EGF-stimulated phosphorylation of CREB1 and histone H3 in'Ser-10', which results in the following transcriptional activation of numerous immediate-early genes.

In response to mitogenic stimulation (EGF and PMA), phosphorylates and activates NR4A1/NUR77 and ETV1/ER81 transcription factors and the cofactor CREBBP. Upon insulin-derived signal, acts indirectly on the transcription regulation of several genes by phosphorylating GSK3B in'Ser-9' and inhibiting its activity.

Gene Information

Human
Gene Name:	RPS6KA3
Uniprot:	P51812
Entrez:	6197

Family

Belongs to:
protein kinase superfamily

Alternative Names

90 kDa ribosomal protein S6 kinase 3; CLS; Coffin-Lowry syndrome; EC 2.7.11; EC 2.7.11.1; HU-3; Insulin-stimulated protein kinase 1; ISPK1; ISPK-1; MAP kinase-activated protein kinase 1b; MAPK-activated protein kinase 1b; MAPKAP kinase 1b; MAPKAPK1B; MAPKAPK-1b; mental retardation, X-linked 19; MRX19; p90-RSK2; p90RSK3; pp90RSK2; ribosomal protein S6 kinase alpha-3; ribosomal protein S6 kinase, 90kD, polypeptide 3; ribosomal protein S6 kinase, 90kDa, polypeptide 3; Ribosomal S6 kinase 2; RPS6KA3; RSK; RSK2; RSK-2; RSK2p90-RSK 3; S6K-alpha3; S6K-alpha-3

Molecular Weight

Mass (kDA):
83.736 kDA

Genomic Context

Human
Location:	Xp22.12
Sequence:	X; NC_000023.11 (20149911..20267514, complement)

Tissue Specificity

Expressed in many tissues, highest levels in skeletal muscle.

Subcellular Localizations

Nucleus. Cytoplasm.

Diseases

• Coffin-lowry Syndrome
• Growth Retardation
• Fragile X Syndrome
• Impaired Cognition
• Malnutrition
• Learning Disabilities
• Hepatitis B
• Carcinoma
• Liver Carcinoma
• Hepatitis
• Muscle Hypotonia

• Epilepsy
• Memory Impairment
• Mild Mental Retardation
• Developmental Delay (disorder)
• Severe Mental Retardation
• Congenital Cerebellar Hypoplasia

Interacting Proteins

• MAPK1

Pathways

• Translation
• Transport
• Neurogenesis
• Synaptic Transmission
• Localization
• Startle Response
• Adult Behavior
• Reverse Transcription
• Cell Death

• Creatine Transport
• Cell Growth
• Exocytosis
• Rna Interference

PTMs

• Phosphorylation

Research Areas

• Cancer
• Protein Kinase

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/RPS6KA3

Best Uses of the RPS6KA3 Marker

What are the best uses for the RPS6KA3 marker Let's start by talking about its background and history. Next, we'll talk about its applications. We will discuss Steven Boster's background and show how he got started. It is a powerful marker which will prove to be of great value to researchers around the globe.

Overview

The RPS6KA3 gene provides instructions for making ribosomal S6 kinases (RSKs), which play important roles in gene activity and signaling within cells. The RSKs have a number cellular functions including cell divisions and specialization. We will discuss the role RPS6KA3 plays in cancer cell invasion, metastasis and other related issues.

The expression pattern of the rps6ka3 gene was found in zebrafish embryos. This suggests that there is a link between this protein and idiopathic spinal stenosis. Researchers have shown that co-injection of rps6ka3 MOs with mapk7 morpholinos partially reversed scoliosis. The study also revealed that coinjection of mapk7 morpholinos with WT human RPs6KA3 mRNA can prevent body curvature.

Knockdown RPS6KA3 resulted in a significant decrease in invading cells in both SKBR3E as well DLKP4E. Both cell lines saw significant decreases in invasion upon knockdown of RPS6KA3. These results support previous studies that have implicated RPS6KA3 in controlling cell invasion. It is clear that RPS6KA3 plays an important role in cell responses.

The RPS6KA3 gene is a downstream target of MAPK7 and is involved in bone resorption. Mutations to the RPS6KA3 gene can lead to skeletal defects and delayed bone formation. RPS6KA3 has a role in osteogenesis. Knockdown results with reduced expression RSK2 osteoblast marker. Osteopenia is caused in mice by the loss RPS6KA3. However, affected mice also display normal osteoblast differentiation as well as a reduced expression for Phex, which regulates the formation of bone mineralization.

Applications

The RPS6KA3 genes provides instructions for making the ribosomal protein 6 kinases (RSKs). These enzymes control gene activity and signalling inside cells. Some researchers have suggested that RSK proteins play important roles in a variety of cellular processes, including cell division and differentiation. Therefore, the RPS6KA3 marker is a useful tool in the identification and diagnosis of conditions affecting ribosomal protein S6 kinases.

Methods for detecting the presence of asbestos

A tumor-associated gene is the ribosomal protein S6-kinase 90 kDa polypeptide 3. It plays an essential role in the proliferation and invasion of cancer cells as well as their migration and metastasis. Depending on the amount of cancer cells that have affected the RPS6KA3 markers, the methods of detection may differ. Detection methods may be performed by conventional or molecular methods.

Steven Boster's history

Steven Boster believed that his family was his greatest priority. He sang in the low register in front of his family and loved sports and auto racing. He was always the first to call when his car started to break down at 2 AM. He also showed up to appointments in below-freezing weather. You can view public records about Boster online, if you are curious about his past. This biography is a tribute for the man who loved and cared about his family.

Steve Boster passed away on June 6, 2022. He was a native of Joliet, IL. He was a long-standing manager in retail sales. He was also a Concordia Hall member in Staunton, VA. Many nieces & nephews also survived him.