RPS6KA2 Antibodies

AND RPS6KA2 ELISA kits, RPS6KA2 Proteins

Many biological assays use antibodies to detect RPS6KA2, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with RPS6KA2 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop RPS6KA2 antibodies...

We validate the specificity of these antibodies to RPS6KA2 by testing them on tissues known to express RPS6KA2 positively and negatively. Browse below to find the RPS6KA2 antibody that suites your experiment. We have 4 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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RPS6KA2 Infographic by Boster Bio

All RPS6KA2 Products

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Product

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Specificity

Applications

Price

Anti-RSK3/RPS6KA2 Antibody Picoband®

1 Q&As

Human, Mouse, Rat

ELISA, IF, IHC, ICC, WB

$370
Cat # A06142-1
100 μg/vial

RSK3 (RPS6KA2) (NM_021135) Human Recombinant Protein

$1062
Cat # PROTQ15349
20 µg

Anti-RSK3 (RPS6KA2) Mouse Monoclonal Antibody [Clone ID: OTI2G5]

Human, Mouse, Rat

$523
Cat # M06142
100 µl

RSK3 (RPS6KA2) (NM_021135) Human Over-expression Lysate

Human

$628
Cat # LS006196
100 µg

RPS6KA2 Overview

Facts about Ribosomal protein S6 kinase alpha-2.

RPS6KA2 3D structure. Source: alphafold

Ribosomal protein S6 kinase alpha-2 (RPS6KA2)

Serine/threonine-protein kinase that acts downstream of ERK (MAPK1/ERK2 and MAPK3/ERK1) signaling and mediates mitogenic and stress-induced activation of transcription factors, regulates translation, and mediates cellular proliferation, survival, and differentiation. May function as tumor suppressor in epithelial ovarian cancer cells.

Gene Information

Human
Gene Name:	RPS6KA2
Uniprot:	Q15349
Entrez:	6196

Family

Belongs to:

protein kinase superfamily

Alternative Names

EC 2.7.11; EC 2.7.11.1; HU-2; MAP kinase-activated protein kinase 1c; MAPK-activated protein kinase 1c; MAPKAP kinase 1c; MAPKAPK1C; MAPKAPK-1c; p90-RSK 2; p90RSK2; p90-RSK3; ribosomal protein S6 kinase alpha 2; ribosomal protein S6 kinase alpha-2; ribosomal protein S6 kinase, 90kD, polypeptide 2; ribosomal protein S6 kinase, 90kDa, polypeptide 2; Ribosomal S6 kinase 3,90 kDa ribosomal protein S6 kinase 2; RPS6KA2; RSK; RSK3; RSK-3; RSK3pp90RSK3; S6K-alpha; S6K-alpha2; S6K-alpha-2

Molecular Weight

Mass (kDA):
83.239 kDA

Genomic Context


Human

Location:	6q27
Sequence:	6; NC_000006.12 (166409364..166862525, complement)

Tissue Specificity

Widely expressed with higher expression in lung, skeletal muscle, brain, uterus, ovary, thyroid and prostate.

Subcellular Localizations

Nucleus. Cytoplasm.

Diseases

Malignant Neoplasms
Neoplasms
Malignant Neoplasm Of Breast
Malignant Tumor Of Colon
Mammary Neoplasms
Rectal Carcinoma
Inflammation
Cholangiocarcinoma
Colonic Neoplasms
Pleural Neoplasms
Carcinogenesis
Immunologic Deficiency Syndromes

Insulin Resistance
Neoplasms, Glandular And Epithelial
Tumor Angiogenesis
Severe Combined Immunodeficiency
Malignant Neoplasm Of Ovary
Epithelial Ovarian Cancer
Colorectal Cancer

Interacting Proteins

BRAF
MAPK1
MAPK3
PRKCE
SCRIB

SHANK1

Pathways

Cell Growth
Energy Homeostasis
Cell Proliferation
Cell Cycle
Angiogenesis
Regulation Of Gene Expression
Ovulation
Regulation Of Cell Growth

Pathogenesis
Localization

PTMs

Phosphorylation

Research Areas

Protein Kinase

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/RPS6KA2

References

PMID: 7623830 by Zhao Y., et al. RSK3 encodes a novel pp90rsk isoform with a unique N-terminal sequence: growth factor-stimulated kinase function and nuclear translocation.

PMID: 8141249 by Moller D.E., et al. Human rsk isoforms: cloning and characterization of tissue-specific expression.