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- Table of Contents
Facts about 40S ribosomal protein S2.
Human | |
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Gene Name: | RPS2 |
Uniprot: | P15880 |
Entrez: | 6187 |
Belongs to: |
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universal ribosomal protein uS5 family |
LLREP3; MGC102851; MGC117344; MGC117345,40S ribosomal protein S4; OK/KNS-cl.6,40S ribosomal protein S2; Protein LLRep3; ribosomal protein S2; RPS4
Mass (kDA):
31.324 kDA
Human | |
---|---|
Location: | 16p13.3 |
Sequence: | 16; NC_000016.10 (1962058..1964826, complement) |
What is Steven Boster’s Bio? What are his Primary Antibodies How did he become a top-notch researcher? Read on to find out more about Steven Boster and his career. You'll also be more informed on this exciting protein. We'll look at his primary antibody and how they affected His career. Now, you can choose the best antibody for your research.
Steven Boster's most popular work, "Flight of the Beef Tenderloin," uses the RPS2 markers to immortalize his personal life with vivid colors. Born in San Angelo Texas, the artist worked as an emergency physician for 33 years. He began painting full-time in 2015, and his studio is located in the Chicken Farm Art Center in San Angelo, Texas. Boster was an avid hunter/outdoorman and used vivid colors as well as a variety of textures when possible to capture his subjects. The sale price of each painting was donated to the Fisher House Foundation which provides meals to veterans in hospital.
His-tag antibodies are highly effective in detecting recombinant His-tagged proteins. His-tag antibody have been approved for use with immunofluorescence and western blot. They can also help with immunological applications such ELISA or flow cytometry. They can also work under denaturing conditions. To learn more about His-tag antibodies and their benefits, check out the following sections.
To determine the size of amplified products, PCR products were electrophoretically resolved on agarose gels and stained with ethidiumbromide. The University of Pennsylvania's Molecular Sequencing Facility confirmed RPS2 fragment identification. Jiang, a journal belonging to the American Society for Molecular Pathology presented the results.
Recent research found that RPS2 overexpression is associated with prostate carcinoma. Overexpression of the protein has been linked to tumor cell survival. However, the suppression of enhanced RPS3a and RPS2 expression inhibits ribosomal biogenesis, leading to apoptosis. Tumor cells overexpressed within S-12 cell-line lines were subjected at apoptosis if this pathway was blocked.
Another approach to identify His primary antibodies is the genetically altered approach. This approach involves altering the antigen protein in an animal. The experimental and knockout samples are treated in the same way as the experimental. The nonfunctional gene prevents expression of the protein of interest, preventing the binding of the primary antibody to tissue. The RPS2 gene is the best candidate for determining if antibodies will bind the protein of interest.
His research on RPS2 indicated that mutations to the chaperone EDS1 could enhance the RPP gene-mediated response. He showed that high-temperature mice were susceptible to growth defects caused by combinations of rps2 points mutations and the tsr4 gene. However, mice lacking the rps2N22 mutation did no significant increase in growth defects. Further research is needed to determine if these mutations enhance responses to rps4mediated signals.
In tumor cells, the RPS2 gene is widely expressed. Overexpression promotes ribosomal biogenesis, thereby promoting tumor cell growth. The tumor cells that are dependent on RPS2 can also be overexpressed. Knocking out RPS2 causes a shutdown of ribosomal Biogenesis and a cascade other apoptotic processes. Knockdown of RPS2 is not likely to have any effect on cell growth, homeostasis, or other aspects.
PMID: 2308862 by Slynn G., et al. Human cDNA sequence homologous to the mouse LLRep3 gene family.
PMID: 8706699 by Vladimirov S.N., et al. Characterization of the human small-ribosomal-subunit proteins by N- terminal and internal sequencing, and mass spectrometry.