Protein fantom Antibodies

AND RPGRIP1L ELISA kits, Protein fantom Proteins

Many biological assays use antibodies to detect Protein fantom, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Protein fantom in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Protein fantom antibodies...

We validate the specificity of these antibodies to Protein fantom by testing them on tissues known to express RPGRIP1L positively and negatively. Browse below to find the RPGRIP1L antibody that suites your experiment. We have 1 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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RPGRIP1L Infographic by Boster Bio

All RPGRIP1L Products

Product

Figures

Specificity

Applications

Price

Anti-RPGRIP1L Antibody Picoband™

Human, Mouse, Rat

ELISA, Flow Cytometry, WB

$370
Cat # A04178-2
100 µg/vial

RPGRIP1L Overview

Facts about Protein fantom.

RPGRIP1L 3D structure. Source: alphafold

Protein fantom (RPGRIP1L)

Negatively regulates signaling through the G-protein coupled thromboxane A2 receptor (TBXA2R) (PubMed:19464661). May be involved in mechanics such as programmed cell death, craniofacial growth, patterning of the limbs, and formation of the left- right axis (By similarity).

Involved in the organization of apical junctions; the purpose is suggested to implicate a NPHP1-4-8 module. Does not appear to be strictly required for ciliogenesis (PubMed:19464661).

Gene Information

Human
Gene Name:	RPGRIP1L
Uniprot:	Q68CZ1
Entrez:	23322

Family

Belongs to:

RPGRIP1 family

Alternative Names

CORS3; FTMDKFZp686C0668; JBTS7fantom homolog; KIAA1005RPGRIP1-like protein; MKS5nephrocystin 8; NPHP8; protein fantom; RPGR-interacting protein 1-like protein; RPGRIP1-like

Molecular Weight

Mass (kDA):
151.201 kDA

Genomic Context


Human

Location:	16q12.2
Sequence:	16; NC_000016.10 (53598153..53703938, complement)

Tissue Specificity

Ubiquitously expressed with relatively high level of expression in hypothalamus and islet. During early development, expressed in multiple organs including brain, eye, forelimb and kidney.

Subcellular Localizations

Cytoplasm. Cytoplasm, cytoskeleton, cilium basal body. Cytoplasm, cytoskeleton, cilium axoneme. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cell junction, tight junction. In cultured renal cells, it localizes diffusely in the cytoplasm but, as cells approach confluence, it accumulates to basolateral tight junctions. Localizes to the ciliary transition zone.

Diseases

Familial Aplasia Of The Vermis
Meckel-gruber Syndrome
Cystic Kidney Diseases
Retinitis Pigmentosa
Nephronophthisis
Kidney Diseases
Ataxia
Cerebellar Diseases
Ciliary Motility Disorders
Congenital Cerebral Hernia
Fibrosis
Polydactyly

Muscle Hypotonia
Dystrophy
Bardet-biedl Syndrome
Obesity
Hepatic Fibrosis
Diabetes Mellitus, Non-insulin-dependent

Interacting Proteins

NPHP4

Pathways

Localization
Pathogenesis
Regulation Of Energy Homeostasis
Smooth Muscle Contraction
Gastrulation
Cell Migration
Developmental Process
Brain Development
Glycosylation
Muscle Contraction
Energy Homeostasis
Platelet Aggregation
Cilium Assembly

Interleukin-6 Production
Chemotaxis
Axon Guidance
Cell Cycle
Brain Morphogenesis
Cognition
Chromosome Condensation

PTMs

Phosphorylation

Cleavage

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/RPGRIP1L

References

PMID: 17558409 by Delous M., et al. The ciliary gene RPGRIP1L is mutated in cerebello-oculo-renal syndrome (Joubert syndrome type B) and Meckel syndrome.

PMID: 17558407 by Arts H.H., et al. Mutations in the gene encoding the basal body protein RPGRIP1L, a nephrocystin-4 interactor, cause Joubert syndrome.