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Roundabout homolog 1 Antibodies
AND ROBO1 ELISA kits, Roundabout homolog 1 Proteins
Many biological assays use antibodies to detect Roundabout homolog 1, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Roundabout homolog 1 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Roundabout homolog 1 antibodies...
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ROBO1 Infographic by Boster Bio
All ROBO1 Products
Product
Figures
Specificity
Applications
Price
Human
ELISA
$750
Cat # EK1755
96 wells/kit, with removable strips.
Cat # EK1755
96 wells/kit, with removable strips.
Human, Mouse, Rat
ELISA, Flow Cytometry, WB
$370
Cat # A01530-2
100 μg/vial
Cat # A01530-2
100 μg/vial
ROBO1 Overview
Facts about Roundabout homolog 1.
Roundabout homolog 1 (ROBO1)
Receptor for SLIT1 and SLIT2 that mediates cellular responses to molecular guidance cues in cellular migration, such as axonal navigation at the ventral midline of the neural tube and projection of axons to different areas during neuronal development (PubMed:10102268, PubMed:24560577). Interaction with the intracellular domain of FLRT3 mediates axon attraction towards cells expressing NTN1 (PubMed:24560577).
In axon growth cones, the silencing of the attractive effect of NTN1 by SLIT2 may require the formation of a ROBO1-DCC complex (By similarity). Plays a role in the regulation of cell migration through its interaction with MYO9B; inhibits MYO9B-mediated stimulation of RHOA GTPase activity, and thereby contributes to increased levels of active, GTP- bound RHOA (PubMed:26529257).
Gene Information
| Human | |
|---|---|
| Gene Name: | ROBO1 |
| Uniprot: | Q9Y6N7 |
| Entrez: | 6091 |
Family
| Belongs to: |
|---|
| immunoglobulin superfamily |
Alternative Names
DUTT1; DUTT1Drosophila) homolog 1; H-Robo-1; MGC131599; MGC133277; ROBO1; roundabout, axon guidance receptor, homolog 1 (Drosophila)
Molecular Weight
Mass (kDA):
180.93 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 3p12.3 |
| Sequence: | 3; NC_000003.12 (78597238..79767998, complement) |
Tissue Specificity
Widely expressed, with exception of kidney.
Subcellular Localizations
Cell membrane; Single-pass type I membrane protein. Cell projection, axon. Endoplasmic reticulum-Golgi intermediate compartment membrane; Single-pass membrane protein. Detected at growth cones in thalamus neurons. Detected at growth cones in thalamus neurons (By similarity). PRRG4 prevents cell surface location and both colocalize in the Endoplasmic reticulum/Golgi adjacent to the cell nucleus (By similarity).
Diseases
- Neoplasms
- Malignant Neoplasms
- Nervousness
- Tumor Angiogenesis
- Carcinoma
- Dyslexia
- Neoplasm Metastasis
- Pathologic Neovascularization
- Cell Invasion
- Cell Transformation, Neoplastic
- Tissue Adhesions
- Mammary Neoplasms
- Malignant Neoplasm Of Breast
Interacting Proteins
- SLIT2
- SRGAP2
Pathways
- Axon Guidance
- Cell Migration
- Angiogenesis
- Chemotaxis
- Tube Formation
- Methylation
- Cell Proliferation
- Endothelial Cell Migration
- Lung Development
- Leukocyte Chemotaxis
- Pathogenesis
- Cell Growth
- Neurogenesis
PTMs
- Methylation
- Demethylation
- Phosphorylation
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/ROBO1
bosterbio.com/bosterbio-gene-info-cards/ROBO1
References
PMID: 9458045 by Kidd T., et al. Roundabout controls axon crossing of the CNS midline and defines a novel subfamily of evolutionarily conserved guidance receptors.
PMID: 10102268 by Brose K., et al. Slit proteins bind Robo receptors and have an evolutionarily conserved role in repulsive axon guidance.