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- Table of Contents
Facts about E3 ubiquitin-protein ligase RNF6.
Mediates 'Lys-6' and 'Lys-27'-linked polyubiquitination of AR/androgen receptor thereby modulating its transcriptional activity. May also bind DNA and function as a transcriptional regulator.
Human | |
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Gene Name: | RNF6 |
Uniprot: | Q9Y252 |
Entrez: | 6049 |
Belongs to: |
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RNF12 family |
DKFZp686P0776; E3 ubiquitin-protein ligase RNF6; EC 6.3.2.-; ring finger protein (C3H2C3 type) 6; RING-H2 protein RNF-6; SPG2
Mass (kDA):
78.091 kDA
Human | |
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Location: | 13q12.13 |
Sequence: | 13; NC_000013.11 (26132115..26223085, complement) |
Weakly expressed in peripheral blood, spleen, prostate, testis and ovary. According to PubMed:18368307, it is preferentially expressed in testis and ovary and hardly detected in other tissues.
Nucleus. Cytoplasm. Cell projection, axon. Nucleus, PML body. Localizes to the PML nuclear bodies in Sertoli cells.
PMID: 10331950 by Macdonald D.H.C., et al. Cloning and characterization of RNF6, a novel RING finger gene mapping to 13q12.
PMID: 18368307 by Zhu L., et al. Cloning and identification of a novel RNF6 transcriptional splice variant Spg2 in human development.