RING finger protein 112 Antibodies

AND RNF112 ELISA kits, RING finger protein 112 Proteins

Many biological assays use antibodies to detect RING finger protein 112, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with RING finger protein 112 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop RING finger protein 112 antibodies...

We validate the specificity of these antibodies to RING finger protein 112 by testing them on tissues known to express RNF112 positively and negatively. Browse below to find the RNF112 antibody that suites your experiment. We have 2 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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RNF112 Infographic by Boster Bio

All RNF112 Products

Product

Figures

Specificity

Applications

Price

ZNF179 (RNF112) (NM_007148) Human Recombinant Protein

$1249
Cat # PROTQ9ULX5
20 µg

ZNF179 (RNF112) (NM_007148) Human Over-expression Lysate

Human

$628
Cat # LS007732
100 µg

RNF112 Overview

Facts about RING finger protein 112.

RNF112 3D structure. Source: alphafold

RING finger protein 112 (RNF112)

E3 ubiquitin-protein ligase that plays a significant role in neuronal differentiation, such as neurogenesis and gliogenesis, during brain development. During embryonic development starts neuronal differentiation by inducing cell cycle arrest in the G0/G1 phase through up-regulation of cell- cycle regulatory proteins (PubMed:28684796).

Plays a role not only in the fetal period during the development of the nervous system, but also in the mature brain, where it is involved in the maintenance of neurological functions and defense of the nervous tissue cells from oxidative stress-induced damage. Exhibits GTPase and E3 ubiquitin-protein ligase activities.

Gene Information

Human
Gene Name:	RNF112
Uniprot:	Q9ULX5
Entrez:	7732

Family

Belongs to:

TRAFAC class dynamin-like GTPase superfamily

Alternative Names

BFPZinc finger protein 179ZNF179Brain finger protein; FLJ99413; ring finger protein 112

Molecular Weight

Mass (kDA):
68.298 kDA

Genomic Context


Human

Location:	17p11.2
Sequence:	17; NC_000017.11 (19406979..19417276)

Tissue Specificity

Predominantly expressed in brain (PubMed:10574464). Decreased expression in glioma brain tumors as compared to normal brains (at protein level) (PubMed:28684796).

Subcellular Localizations

Membrane; Multi-pass membrane protein. Membrane; Peripheral membrane protein. Cytoplasm. Nucleus. Nucleus, nuclear body. Nucleus, nucleoplasm. Endosome. Cytoplasmic vesicle, secretory vesicle, synaptic vesicle. Cell junction, synapse, postsynaptic density. Perikaryon. Cell projection, neuron projection. Predominantly in the nucleus, but some amounts were also found in the cytoplasm. Oxidative stress stimulates its shuttling from the cytoplasm into the nucleus. Recruited to nuclear bodies via its interaction with ZBTB16. Localizes to the cell soma and neuritis and only slightly to the nucleus i

PTMs

Ubl conjugation

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/RNF112

References

PMID: 10574464 by Seki N., et al. cDNA cloning of a human brain finger protein, BFP/ZNF179, a member of the RING finger protein family.

PMID: 8660987 by Matsuda Y., et al. Chromosome mapping of human (ZNF179), mouse, and rat genes for brain finger protein (bfp), a member of the RING finger family.