RND1 Antibodies

Rho-related GTP-binding protein Rho6 (RND1)

Lacks intrinsic GTPase activity. Has a very low affinity for GDP, and constitutively binds GTP.

Controls rearrangements of the actin cytoskeleton. Induces the Rac-dependent neuritic process formation in part by disruption of the cortical actin filaments.

Gene Information

Human
Gene Name:	RND1
Uniprot:	Q92730
Entrez:	27289

Family

Belongs to:
small GTPase superfamily

Alternative Names

ARHS; GTP-binding protein; ras homolog gene family, member S; Rho family GTPase 1FLJ42294; RHO6; rho-related GTP-binding protein Rho6; RHOS; Rnd1

Molecular Weight

Mass (kDA):
26.056 kDA

Genomic Context

Human
Location:	12q13.12
Sequence:	12; NC_000012.12 (48857145..48865870, complement)

Tissue Specificity

Mostly expressed in brain and liver.

Subcellular Localizations

Cell membrane; Lipid-anchor; Cytoplasmic side. Cytoplasm, cytoskeleton.

Diseases

• Tissue Adhesions
• Neoplasm Metastasis
• Malignant Neoplasms
• Neoplasms
• Nervousness
• Cell Invasion
• Nervous System Disorder
• Premature Obstetric Labor
• Wolfram Syndrome
• Feeling Despair
• Mood Disorders
• Varicosity

• Malignant Neoplasm Of Breast
• Carcinoma 256, Walker
• Neoplasm Invasiveness
• Degenerative Polyarthritis
• Depression And Suicide
• Cardiovascular Diseases

Interacting Proteins

• GRB7
• PLXNB1
• PLXNB2

Pathways

• Cell Adhesion
• Axon Guidance
• Cell Migration
• Sensitization
• Cell Cycle
• Localization
• Dendrite Development
• Translation
• Cell Motility
• Receptor Clustering
• Cell Growth
• Regulation Of Dendrite Development
• Cell Fate Specification

• Cytoskeleton Organization
• Axon Extension
• Mrna Transcription
• Estrus
• Segmentation
• Oncogenesis
• Actin Cytoskeleton Organization

PTMs

• Phosphorylation
• Farnesylation

• Prenylation
• Ubiquitination

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/RND1

Boster Bio: Best Uses Of The RND1 Marker

The RND1/Rnd3 interaction with P65 is one of the most fascinating properties of the antisense RNA molecule. This article explains the interactions between antisense molecules of RNA and the cell's nucleus. Boster Bio: Anti Histone H3, a antisenseRNA molecule also plays an important part in cancer research.

RND1/Rnd3 interacts with P65

RND1/Rnd3 are upregulated in many human cancers. This leads to the overexpression ADAMTS1. ADAMTS1 is only activated when the P65 genetic code is present. It is also downregulated when the P65 gene does not exist. RND1/Rnd3 don't work, but they interact with P65. They are both necessary for cancer cell-growth.

Boster Bio: Anti-phospho-(p-)inhibitor of NF-kB-a

Anti-phospho-(p-)immunoglobulin G (p65) is a highly specific antibody that reacts with NF-kB a. This antibody has been tested against rat and mouse samples. This antibody can both be used in ELISA and WB applications.

Many aspects of cellular process are controlled through NF-kB dependent transcription factors. They regulate gene expression to respond to environmental stimuli. They include members from the antiapoptotic Bcl Family, cyclins and growth factor. NFkB plays a crucial role in cell survival, proliferation, and differentiation. It also regulates immunity.

When IKKb phosphorylates carboxyterminal serine residues, p105 undergoes complete degradation. This phosphorylation is independent from ubiquitination, which allows p105 degrading. This process is favorably facilitated by NF-kB.

There are many implications for activated NF-kB-1a. It is involved in the regulation and apoptosis of mitochondrions. A study by Liu et al. (2004) showed that NF-kB-a-mediated autophagy resulted in the release of cytochrome c, which is responsible for electron transfer from Complex III to Complex IV. It activates the caspases.

Two subgroups of NFKB family proteins are categorized based upon their transactivation potential. p65 is composed of carboxy-terminal transcription domains, whereas p50/cRel are composed of amino-terminal lesucine zipper regions. Additionally, p50/c-Rel and p52 are made from the processing precursor molecules.

The pivotal regulator of immune function is NF-kB. It is responsible for inducing pro-inflammatory gene transcription, participating in inflammasome regulatory, and regulating survival and differentiation of innate immunity cells. Its disruption is implicated in inflammatory disease, and inhibiting its activity is an effective way of preventing it.

This blocking peptide can be very beneficial in your research. If you have a specific research project or development goal in mind, the manufacturer can help you purchase the peptide. Be sure to contact the company directly for pricing information. Then, you can use the specific peptide to treat your disease. Although you may be familiarized with NF-kB you will be surprised at its importance to mitochondrial functions.

Boster Bio: Anti-Histone H3

Steven Boster was the original inventor of the RND1 mark in 1993. This product was originally based on the neutral-red assay. It measures the cellular protein contents. The RND1 marker can be used to determine cell viability or for proliferation studies. Its use in detecting cancer cells and other cancer-related proteins is highly specific. It is sensitive enough to measure protein levels in cell culture media and other biological samples.