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- Table of Contents
Facts about Rho family-interacting cell polarization regulator 2.
Involved also in the regulation of neutrophil polarization, chemotaxis and adhesion (By similarity). Required for normal development of outer and inner hair cell stereocilia within the cochlea of the inner ear (By similarity).
Human | |
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Gene Name: | RIPOR2 |
Uniprot: | Q9Y4F9 |
Entrez: | 9750 |
Belongs to: |
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RIPOR family |
Rho family-interacting cell polarization regulator 2
Mass (kDA):
118.519 kDA
Human | |
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Location: | 6p22.3 |
Sequence: | 6; NC_000006.12 (24804284..25042288, complement) |
Expressed in primary fetal mononuclear myoblast (PubMed:17150207). Expressed strongly in naive T lymphocytes (PubMed:27556504). Expressed weakly in activated T lymphocytes (at protein level) (PubMed:27556504). Expressed in blood cells and adult tissues of hematopoietic origin, such as the secondary lymphoid organs (PubMed:23241886). Expressed in cytotrophoblast (PubMed:9055809).
Cytoplasm. Cytoplasm, cytoskeleton. Cell projection, filopodium. Cell projection, stereocilium. Cell projection, stereocilium membrane. Apical cell membrane. Localized in the cytoplasm in cells undergoing mitosis (PubMed:17150207). Colocalized with F-actin (PubMed:17150207). Localized with RHOC within the basal domain of hair cell stereocilia, near the taper region (By similarity). Detected in punctate pattern forming a circumferential ring at the stereocilia base (By similarity). Localized to the apical stereocilia of inner and outer hair cells (By similarity). Not detected as a membrane-asso
PMID: 9055809 by Dakour J., et al. PL48: a novel gene associated with cytotrophoblast and lineage- specific HL-60 cell differentiation.
PMID: 17150207 by Yoon S., et al. C6ORF32 is upregulated during muscle cell differentiation and induces the formation of cellular filopodia.