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RIPK2 Antibodies
AND RIPK2 ELISA kits, RIPK2 Proteins
Many biological assays use antibodies to detect RIPK2, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with RIPK2 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop RIPK2 antibodies...
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RIPK2 Infographic by Boster Bio
All RIPK2 Products
Product
Figures
Specificity
Applications
Price
Human, Mouse
ELISA
$480
Cat # EKC1506
1 kit, containing one 96-well plate and all necessary reagents
Cat # EKC1506
1 kit, containing one 96-well plate and all necessary reagents
Human, Mouse
ELISA
$540
Cat # EKC2582
1 kit, containing two 96-well plates and all necessary reagents
Cat # EKC2582
1 kit, containing two 96-well plates and all necessary reagents
RIPK2 Overview
Facts about Receptor-interacting serine/threonine-protein kinase 2.
Receptor-interacting serine/threonine-protein kinase 2 (RIPK2)
Serine/threonine/tyrosine kinase that plays an essential role in modulation of innate and adaptive immune responses. Upon stimulation by bacterial peptidoglycans, NOD1 and NOD2 are triggered, oligomerize and recruit RIPK2 through CARD-CARD domain names.
Contributes to the tyrosine phosphorylation of the guanine exchange factor ARHGEF2 via Src tyrosine kinase resulting in NF-kappaB activation by NOD2. The polyubiquitinated protein mediates the recruitment of MAP3K7/TAK1 into IKBKG/NEMO and induces'Lys-63'-linked polyubiquitination of IKBKG/NEMO and subsequent activation of IKBKB/IKKB.
Gene Information
| Human | |
|---|---|
| Gene Name: | RIPK2 |
| Uniprot: | O43353 |
| Entrez: | 8767 |
Family
| Belongs to: |
|---|
| protein kinase superfamily |
Alternative Names
CARD3; CARD-containing IL-1 beta ICE-kinase; CARD-containing interleukin-1 beta-converting enzyme (ICE)-associated kinase; CARD-containing interleukin-1 beta-converting enzyme-associated kinase; CARDIAKCCK; EC 2.7.11; EC 2.7.11.1; GIG30; growth-inhibiting gene 30; receptor interacting protein 2; receptor-interacting protein (RIP)-like interacting caspase-like apoptosisregulatory protein (CLARP) kinase; Receptor-interacting protein 2; receptor-interacting serine/threonine-protein kinase 2; receptor-interacting serine-threonine kinase 2; RICK; RICKGIG30; RIP2; RIP-2; RIP2CARD-carrying kinase; RI
Molecular Weight
Mass (kDA):
61.195 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 8q21.3 |
| Sequence: | 8; NC_000008.11 (89757816..89791064) |
Tissue Specificity
Detected in heart, brain, placenta, lung, peripheral blood leukocytes, spleen, kidney, testis, prostate, pancreas and lymph node.
Subcellular Localizations
Cytoplasm.
Diseases
- Inflammation
- Crohn Disease
- Innate Immune Response
- Neoplasms
- Inflammatory Response
- Pneumonia
- Listeriosis
- Infective Disorder
- Systemic Infection
- Salmonella Infections
- Bacterial Infections
- Colitis
- Ulcer
Interacting Proteins
- BIRC2
- BIRC3
- CARD6
- MAVS
- NOD1
- NOD2
- TRAF3
- XIAP
Pathways
- Secretion
- Immune Response
- Pathogenesis
- Cell Death
- Cytokine Production
- Innate Immune Response
- Inflammatory Response
- Cell Activation
- Chemokine Production
- Autophagy
- Cell Proliferation
- Cytokine Secretion
- Regeneration
PTMs
- Phosphorylation
- Cleavage
Research Areas
- Apoptosis
- Cancer
- Tumor Suppressors
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/RIPK2
bosterbio.com/bosterbio-gene-info-cards/RIPK2
References
PMID: 9575181 by Inohara N., et al. RICK, a novel protein kinase containing a caspase recruitment domain, interacts with CLARP and regulates CD95-mediated apoptosis.
PMID: 9642260 by McCarthy J.V., et al. RIP2 is a novel NF-kappaB-activating and cell death-inducing kinase.