Receptor-interacting serine/threonine-protein kinase 1 (RIPK1)

Serine-threonine kinase which transduces inflammatory and cell-death signs (programmed necrosis) following death receptors ligation, activation of pathogen recognition receptors (PRRs), and DNA damage (PubMed:11101870, PubMed:17389591, PubMed:19524512, PubMed:19524513). Upon activation of TNFR1 from the TNF-alpha family cytokines, TRADD and TRAF2 are recruited to the receptor (PubMed:11101870, PubMed:17389591, PubMed:19524512, PubMed:19524513).

Phosphorylates DAB2IP in'Ser-728' at a TNF- alpha-dependent fashion, and thereby activates the MAP3K5-JNK apoptotic cascade (PubMed:17389591). Ubiquitination by TRAF2 through'Lys-63'-link chains acts as a critical enhancer of communication with downstream signal transducers in the mitogen-activated protein kinase pathway and the NF-kappa-B pathway, which then mediate downstream events such as the activation of genes encoding inflammatory molecules (PubMed:15258597).