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- Table of Contents
Facts about Rhodopsin.
Light-induced isomerization of the chromophore 11-cis-retinal to all-trans-retinal triggers a conformational change that activates signaling via G-proteins (PubMed:8107847, PubMed:28524165, PubMed:26200343, PubMed:28753425). Subsequent receptor phosphorylation mediates displacement of the bound G- protein alpha subunit by the arrestin SAG and terminates signaling (PubMed:28524165, PubMed:26200343).
Human | |
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Gene Name: | RHO |
Uniprot: | P08100 |
Entrez: | 6010 |
Belongs to: |
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G-protein coupled receptor 1 family |
CSNBAD1; MGC138309; OPN2MGC138311; opsin 2, rod pigment; opsin-2; retinitis pigmentosa 4, autosomal dominant; rhodopsin; RP4
Mass (kDA):
38.893 kDA
Human | |
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Location: | 3q22.1 |
Sequence: | 3; NC_000003.12 (129528639..129535344) |
Rod shaped photoreceptor cells which mediate vision in dim light.
Membrane; Multi-pass membrane protein. Cell projection, cilium, photoreceptor outer segment. Synthesized in the inner segment (IS) of rod photoreceptor cells before vectorial transport to disk membranes in the rod outer segment (OS) photosensory cilia.
PMID: 6589631 by Nathans J., et al. Isolation and nucleotide sequence of the gene encoding human rhodopsin.
PMID: 8566799 by Bennett J., et al. Sequence analysis of the 5.34-kb 5' flanking region of the human rhodopsin-encoding gene.