This website uses cookies to ensure you get the best experience on our website.
- Table of Contents
, No Gclids
RGS14 Antibodies
AND RGS14 ELISA kits, RGS14 Proteins
Many biological assays use antibodies to detect RGS14, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with RGS14 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop RGS14 antibodies...
Previous: CCN4
Next: LEFTY1
RGS14 Infographic by Boster Bio
All RGS14 Products
Product
Figures
Specificity
Applications
Price
RGS14 Overview
Facts about Regulator of G-protein signaling 14.
Regulator of G-protein signaling 14 (RGS14)
Regulates G protein-coupled receptor signaling cascades. Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits, thereby driving them into their inactive GDP-bound form.
Besides, modulates signal transduction via G protein alpha subunits by functioning as a GDP-dissociation inhibitor (GDI). Has GDI activity on G(I) alpha subunits GNAI1 and GNAI3, but not on GNAI2 and G(o) alpha subunit GNAO1.
Gene Information
| Human | |
|---|---|
| Gene Name: | RGS14 |
| Uniprot: | O43566 |
| Entrez: | 10636 |
Family
| Belongs to: |
|---|
| No superfamily |
Alternative Names
regulator of G-protein signaling 14; regulator of G-protein signalling 14
Molecular Weight
Mass (kDA):
61.447 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 5q35.3 |
| Sequence: | 5; NC_000005.10 (177357672..177372601) |
Subcellular Localizations
Nucleus. Nucleus, PML body. Cytoplasm. Membrane. Cell membrane. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, spindle. Cytoplasm, cytoskeleton, spindle pole. Cell projection, dendrite. Cell projection, dendritic spine. Cell junction, synapse, postsynaptic density. Associates with the perinuclear sheaths of microtubules (MTs) surrounding the pronuclei, prior to segregating to the anastral mitotic apparatus and subsequently the barrel-shaped cytoplasmic bridge between the nascent nuclei of the emerging 2-cell embryo. Localizes to a perinuclear compa
Diseases
- Nervousness
- Malignant Neoplasms
- Cholangiocarcinoma
- Leukoencephalopathy, Progressive Multifocal
- Lymphomatoid Granulomatosis
- Neurodegenerative Disorders
- Colonic Neoplasms
- Malignant Tumor Of Colon
- Carcinogenesis
- Parkinson Disease
- Cardiovascular Diseases
- Acute Promyelocytic Leukemia
- Pain
Interacting Proteins
- GNAI3
- TINF2
Pathways
- Localization
- Cell Division
- Mitosis
- Cell Growth
- Asymmetric Cell Division
- Cell Activation
- Cell Migration
- Interphase
- Lymphocyte Migration
- Spindle Organization
- Transport
- Protein Phosphorylation
- B Cell Activation
PTMs
- Phosphorylation
- Oxidation
Research Areas
- Signal Transduction
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/RGS14
bosterbio.com/bosterbio-gene-info-cards/RGS14
References
PMID: 16819986 by Lopez-Aranda M.F., et al. Localization of the GoLoco motif carrier regulator of G-protein signalling 12 and 14 proteins in monkey and rat brain.
PMID: 15917656 by Martin-McCaffrey L., et al. RGS14 is a microtubule-associated protein.