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- Table of Contents
Facts about Proto-oncogene c-Rel.
The dimers bind at kappa-B sites in the DNA of their target genes and the individual dimers have distinct preferences for different kappa-B sites which they can bind with distinguishable affinity and specificity. Different dimer combinations act as transcriptional activators or repressors, respectively.
Human | |
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Gene Name: | REL |
Uniprot: | Q04864 |
Entrez: | 5966 |
Belongs to: |
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No superfamily |
C-Rel proto-oncogene protein; cRel; c-Rel; I-Rel; oncogene REL, avian reticuloendotheliosis; proto-oncogene c-Rel; REL; v-rel avian reticuloendotheliosis viral oncogene homolog; v-rel reticuloendotheliosis viral oncogene homolog (avian)
Mass (kDA):
68.52 kDA
Human | |
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Location: | 2p16.1 |
Sequence: | 2; NC_000002.12 (60881521..60931612) |
Nucleus.
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Boster Bio AntiMacrosialInCD68 Monoclonal Monoclonal Monoclonal MonoclonalAntibody recognizes the CD68 protein. It is approved for IHC–P application. This antibody reacts also with Human, Rat, and Mouse samples. It is non-immune-specific and does not block tetracytokines.
The protein is highly glycosylated and is an integral part of the membrane protein. It is closely related to Lysosomal/endosomal (LAMP) Glycoproteins. CD68 is widely used as a pan-macrophage marker and is present in low levels on Langerhans cells and conventional dendritic cells. CD68 is found mainly in late endosomes and lysosomes, with only a small fraction circulating at the cell surface. Cell stimulation can induce it, which results in glycoform remodeling and transport to cells surface.
CD68 is a 110 kDa membrane glycoprotein. It belongs to the LAMP (lysosomal-associated membrane protein) family and plays an important role in macrophage recruitment and activation. It is located primarily in the lysosome, but can also be found on the cell surface. However, it is thought that CD68 has a role in atherosclerosis.
Boster Bio Anti-Macrosial Inate Receptor (REL Marker) binds specifically to tissue lectins, and targets tumor cell. It is an excellent tool for studying the immune response to tumor cells in vitro. It is highly recommended for all immunohistochemical studies of cancer cells. Boster Bio Anti-Macrosialin CD68 Monoclonal Antibody uses REL marker and is highly precise.
PMID: 2666912 by Brownell E., et al. A human rel proto-oncogene cDNA containing an Alu fragment as a potential coding exon.
PMID: 3016517 by Brownell E., et al. Genetic characterization of human c-rel sequences.