RECQL5 Antibodies

AND RECQL5 ELISA kits, RECQL5 Proteins

Many biological assays use antibodies to detect RECQL5, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with RECQL5 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop RECQL5 antibodies...

We validate the specificity of these antibodies to RECQL5 by testing them on tissues known to express RECQL5 positively and negatively. Browse below to find the RECQL5 antibody that suites your experiment. We have 0 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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RECQL5 Infographic by Boster Bio

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RECQL5 Overview

Facts about ATP-dependent DNA helicase Q5.

RECQL5 3D structure. Source: alphafold

ATP-dependent DNA helicase Q5 (RECQL5)

Isoform beta is a DNA helicase that plays an important role in DNA replication, transcription and repair. Inhibits elongation of postponed transcripts in DNA damage sites by binding to the RNA polymerase II subunit POLR2A and blocking the TCEA1 binding site.

Required for mitotic chromosome separation after cross-over occasions and cell cycle progress. Required for efficient DNA repair, including repair of inter-strand cross-links.

Gene Information

Human
Gene Name:	RECQL5
Uniprot:	O94762
Entrez:	9400

Family

Belongs to:

helicase family

Alternative Names

DNA helicase, RecQ-like type 5; EC 3.6.1; EC 3.6.4.12; FLJ90603; RecQ protein-like 5ATP-dependent DNA helicase Q5; RecQ5; RECQ5RecQ protein 5

Molecular Weight

Mass (kDA):
108.858 kDA

Genomic Context


Human

Location:	17q25.1
Sequence:	17; NC_000017.11 (75626845..75667202, complement)

Tissue Specificity

Ubiquitous.

Subcellular Localizations

[Isoform Beta]: Nucleus, nucleoplasm. Recruited to sites of DNA damage, such as single-strand breaks and inter-strand cross-links, and at stalled replication forks.; [Isoform Alpha]: Cytoplasm.; [Isoform Gamma]: Cytoplasm.

Diseases

Malignant Neoplasms
Genomic Instability
Rothmund-thomson Syndrome
Bloom Syndrome
Werner Syndrome
Neoplasms
Premature Aging Syndrome
Hereditary Diseases
Instabilities, Chromosomal
Malignant Tumor Of Colon
Cell Transformation, Neoplastic
Multiple Endocrine Neoplasia Type 1

Adenoma
Dna Injury
Malignant Neoplasm Of Breast
Colonic Neoplasms
Neoplasms, Experimental
Duodenal Neoplasms
Ileal Neoplasms

Interacting Proteins

POLR2A

Pathways

Dna Replication
Dna Repair
Aging
Cell Cycle
Dna Recombination
Localization
Mitosis
Chromosome Segregation
Cell Cycle Arrest
Cell Death
Metaphase
Double-strand Break Repair
Translesion Synthesis

Telomere Maintenance
S Phase
Cell Differentiation
Chromatin Organization
Cell Growth
Bone Development
Rna Interference

PTMs

Phosphorylation

Cleavage

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/RECQL5

References

PMID: 9878247 by Kitao S., et al. Cloning of two new human helicase genes of the RecQ family: biological significance of multiple species in higher eukaryotes.

PMID: 10471747 by Sekelsky J.J., et al. Drosophila and human RecQ5 exist in different isoforms generated by alternative splicing.