RCHY1 Antibodies

AND RCHY1 ELISA kits, RCHY1 Proteins

Many biological assays use antibodies to detect RCHY1, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with RCHY1 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop RCHY1 antibodies...

We validate the specificity of these antibodies to RCHY1 by testing them on tissues known to express RCHY1 positively and negatively. Browse below to find the RCHY1 antibody that suites your experiment. We have 5 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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RCHY1 Infographic by Boster Bio

All RCHY1 Products

Filter by Application:

Product

Figures

Specificity

Applications

Price

Anti-Pirh2 RCHY1 Monoclonal Antibody

Human, Rat

ELISA, Flow Cytometry, IF, IHC, WB

$380
Cat # M04533
100ul

Pirh2 (RCHY1) (NM_015436) Human Recombinant Protein

$813
Cat # PROTQ96PM5
20 µg

Anti-RCHY1 Rabbit Monoclonal Antibody

Human, Mouse

IP, IF, ICC, WB

$370
Cat # M04533-1
100 μl/vial

Pirh2 (RCHY1) (NM_015436) Human Over-expression Lysate

Human

$628
Cat # LS025898
100 µg

Anti-Pirh2/RCHY1 Antibody Picoband®

Human, Mouse, Rat

ELISA, Flow Cytometry, WB

$370
Cat # A04533-3
100 µg/vial

RCHY1 Overview

Facts about RING finger and CHY zinc finger domain-containing protein 1.

RCHY1 3D structure. Source: alphafold

RING finger and CHY zinc finger domain-containing protein 1 (RCHY1)

Mediates E3-dependent ubiquitination and proteasomal degradation of target proteins, including p53/TP53, P73, HDAC1 and CDKN1B. Preferentially acts on tetrameric p53/TP53.

Monoubiquitinates the translesion DNA polymerase POLH. Contributes to the regulation of the cell cycle progression.

Gene Information

Human
Gene Name:	RCHY1
Uniprot:	Q96PM5
Entrez:	25898

Family

Belongs to:

No superfamily

Alternative Names

Androgen receptor N-terminal-interacting protein; androgen-receptor N-terminal-interacting protein; ARNIPRING finger protein 199; CHIMPRNF199DKFZp586C1620; CH-rich interacting match with PLAG1; CH-rich-interacting match with PLAG1; E3 ubiquitin-protein ligase Pirh2; EC 6.3.2.-; hARNIP; hPirh2; PIRH2; PRO1996; ring finger and CHY zinc finger domain containing 1; RING finger and CHY zinc finger domain-containing protein 1; Zinc finger protein 363p53-induced RING-H2 protein; ZNF363

Molecular Weight

Mass (kDA):
30.11 kDA

Genomic Context


Human

Location:	4q21.1
Sequence:	4; NC_000004.12 (75479037..75515057, complement)

Subcellular Localizations

Nucleus. Nucleus speckle. Cytoplasm.

Diseases

Neoplasms
Malignant Neoplasms
Carcinoma
Cell Transformation, Neoplastic
Liver Carcinoma
Liver Neoplasms
Neoplasm Metastasis
Malignant Paraganglionic Neoplasm
Malignant Neoplasm Of Lung
Carcinogenesis
Non-small Cell Lung Carcinoma
Lung Neoplasms
Xeroderma

Xeroderma Pigmentosum
Prostatic Neoplasms
Genotoxic Stress
Measles
Cell Invasion
Malignant Neoplasm Of Prostate
Acquired Immunodeficiency Syndrome

Interacting Proteins

AIG1
ANGPTL8
ARF4
HRG
KLHL41

KRTAP9-2
MEOX2
NKD2
NLK
NOTCH2NL

SEMA4C
TP53
UBASH3B
WDR74

Pathways

Cell Proliferation
Localization
Cell Cycle
Proteolysis
Cell Cycle Arrest
Cell Growth
Pathogenesis
Transport
Cell Migration
Endocytosis
Senescence
Viral Transcription

Cell Motility
Cell Death
S Phase
Exocytosis
Secretion
Oncogenesis

PTMs

Ubiquitination

Phosphorylation

Research Areas

Apoptosis
Breast Cancer
Cancer
p53 Pathway
Tumor Suppressors

Ubiquitin Proteasome Pathway
Zinc Finger

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/RCHY1

References

PMID: 19483087 by Corcoran C.A., et al. Identification and characterization of two novel isoforms of Pirh2 ubiquitin ligase that negatively regulate p53 independent of RING finger domains.

PMID: 20452352 by Wu G., et al. A novel hPirh2 splicing variant without ubiquitin protein ligase activity interacts with p53 and is down-regulated in hepatocellular carcinoma.