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- Table of Contents
Facts about Regulator of chromosome condensation.
Via its role in maintaining high levels of GTP-bound RAN in the nucleus, contributes to the discharge of cargo proteins from importins after nuclear import (PubMed:22215983). Involved in the regulation of onset of chromosome condensation in the S phase (PubMed:3678831).
Human | |
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Gene Name: | RCC1 |
Uniprot: | P18754 |
Entrez: | 1104 |
Belongs to: |
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No superfamily |
Cell cycle regulatory protein; CHC1RCC1-I; chromosome condensation 1; Chromosome condensation protein 1; guanine nucleotide-releasing protein; regulator of chromosome condensation 1; regulator of chromosome condensation; SNHG3-RCC1 readthrough transcript; SNHG3-RCC1
Mass (kDA):
44.969 kDA
Human | |
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Location: | 1p35.3 |
Sequence: | 1; NC_000001.11 (28505943..28539300) |
Nucleus. Chromosome. Cytoplasm. Predominantly nuclear in interphase cells (PubMed:12194828). Binds to mitotic chromosomes (PubMed:12194828, PubMed:17435751, PubMed:20668449).
PMID: 3678831 by Ohtsubo M., et al. Isolation and characterization of the active cDNA of the human cell cycle gene (RCC1) involved in the regulation of onset of chromosome condensation.
PMID: 1769659 by Furuno N., et al. Complete nucleotide sequence of the human RCC1 gene involved in coupling between DNA replication and mitosis.