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RNA-binding protein 4 Antibodies
AND RBM4 ELISA kits, RNA-binding protein 4 Proteins
Many biological assays use antibodies to detect RNA-binding protein 4, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with RNA-binding protein 4 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop RNA-binding protein 4 antibodies...
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RBM4 Overview
Facts about RNA-binding protein 4.
RNA-binding protein 4 (RBM4)
RNA-binding factor involved in numerous aspects of cellular processes like alternative splicing of pre-mRNA and translation regulation. Modulates option 5'-splice site and exon choice.
Acts as a muscle cell differentiation-promoting factor. Activates exon skipping of the PTB pre-mRNA during muscle cell differentiation.
Gene Information
| Human | |
|---|---|
| Gene Name: | RBM4 |
| Uniprot: | Q9BWF3 |
| Entrez: | 5936 |
Family
| Belongs to: |
|---|
| No superfamily |
Alternative Names
DKFZp547K0918; FLJ36727; hLark; Lark homolog; MGC75138; RBM4. LARK; RBM4ALARK; RNA binding motif protein 4; RNA-binding motif protein 4; RNA-binding motif protein 4a; RNA-binding protein 4; transcriptional coactivator CoAZ; ZCCHC21; ZCRB3A; zinc finger CCHC-type and RNA binding motif 3A
Molecular Weight
Mass (kDA):
40.314 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 11q13.2 |
| Sequence: | 11; NC_000011.10 (66638617..66668380) |
Tissue Specificity
Expressed in the cerebellum. Expressed in neurons and glial cells, including layers II neurons in the frontal cortex and CA1 pyramidal neurons in the hippocampus. Expressed in heart, liver, pancreas, skeletal muscle, placenta, primary fibroblasts and peripheral blood monocytes (at protein level). Ubiquitously expressed. Highly expressed in heart, placenta and skeletal muscle. Weakly expressed in pancreas, kidney, liver, lung and brain.
Subcellular Localizations
Nucleus. Nucleus, nucleolus. Nucleus speckle. Cytoplasm. Cytoplasmic granule. Undergoes continuous nucleocytoplasmic shuttling. Upon nuclear import colocalizes with SR proteins in nuclear speckles. Arsenite stress-induced phosphorylation increases its subcellular relocalization from the nucleus to the cytoplasm and to cytoplasmic stress granules (SG) via a p38 MAPK signaling pathway. Primarily localized in nucleus and nucleoli under cell growth conditions and accumulated in the cytoplasm and cytoplasm perinuclear granules upon muscle cell differentiation.
Diseases
- Malignant Neoplasms
- Tauopathies
- Embryonal Carcinoma
- Neurodegenerative Disorders
- Dementia
- Down Syndrome
- Hypoxia
- Physiological Stress
- Nephroblastoma
- Systemic Infection
Interacting Proteins
- EIF4A1
- EIF4G1
- EPAS1
Pathways
- Translation
- Cell Differentiation
- Muscle Cell Differentiation
- Localization
- Mrna Splicing
- Transport
- Rna Processing
- Response To Stress
- Circadian Rhythm
- Signal Transmission
PTMs
- Phosphorylation
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/RBM4
bosterbio.com/bosterbio-gene-info-cards/RBM4
References
PMID: 9169144 by Jackson F.R., et al. A novel zinc finger-containing RNA-binding protein conserved from fruitflies to humans.
PMID: 12469345 by Bernert G., et al. Manifold decreased protein levels of matrin 3, reduced motor protein HMP and hlark in fetal Down's syndrome brain.