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RNA-binding protein 14 Antibodies
AND RBM14 ELISA kits, RNA-binding protein 14 Proteins
Many biological assays use antibodies to detect RNA-binding protein 14, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with RNA-binding protein 14 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop RNA-binding protein 14 antibodies...
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RBM14 Infographic by Boster Bio
All RBM14 Products
Product
Figures
Specificity
Applications
Price
Human
ELISA, Flow Cytometry, IF, ICC, WB
$370
Cat # A04917-2
100 µg/vial
Cat # A04917-2
100 µg/vial
RBM14 Overview
Facts about RNA-binding protein 14.
RNA-binding protein 14 (RBM14)
Isoform 1 may be a nuclear receptor coactivator, enhancing transcription through other coactivators like NCOA6 and CITED1. Isoform 2, functions as a transcriptional repressor, regulating transcriptional activities of coactivators including isoform 1, NCOA6 and CITED1 (PubMed:11443112).
Regulates centriole biogenesis by suppressing the formation of aberrant centriolar protein complexes in the cytoplasm and so preserving mitotic spindle integrity. Prevents the formation of the STIL-CENPJ complicated (which could induce the formation of aberrant centriolar protein complexes) by interfering with the interaction of STIL with CENPJ (PubMed:25385835).
Gene Information
| Human | |
|---|---|
| Gene Name: | RBM14 |
| Uniprot: | Q96PK6 |
| Entrez: | 10432 |
Family
| Belongs to: |
|---|
| No superfamily |
Alternative Names
COAAMGC31756; Paraspeckle protein 2; PSP2DKFZp779J0927; RNA binding motif protein 14; RNA-binding motif protein 14; RNA-binding protein 14; RRM-containing coactivator activator/modulator; SIPMGC15912; Synaptotagmin-interacting protein; SYT-interacting protein; SYTIP1; TMEM137; transmembrane protein 137
Molecular Weight
Mass (kDA):
69.492 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 11q13.2 |
| Sequence: | 11; NC_000011.10 (66616630..66629934) |
Subcellular Localizations
Nucleus. Nucleus, nucleolus. Cytoplasm. In punctate subnuclear structures often located adjacent to splicing speckles, called paraspeckles (PubMed:11790299). Cytoplasmic localization is crucial for its function in suppressing the formation of aberrant centriolar protein complexes (PubMed:25385835).
Diseases
- Malignant Neoplasms
- Carcinoma
- Neoplasms
- Neoplasm Metastasis
- Sarcoma
- Cell Transformation, Neoplastic
- Synovial Sarcoma
- Malignant Neoplasm Of Kidney
- Squamous Cell Carcinoma Of Skin
- Embryonal Carcinoma
- Muscular Fasciculation
- Neurodegenerative Disorders
- Tdp-43 Proteinopathies
Interacting Proteins
- CRLF3
- HNRNPK
Pathways
- Rna Splicing
- Localization
- Methylation
- Chemotaxis
- Cell Differentiation
- Hypersensitivity
- Regulation Of Gene Expression
- Rna Processing
- Ovulation
PTMs
- Acetylation
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/RBM14
bosterbio.com/bosterbio-gene-info-cards/RBM14
References
PMID: 11443112 by Iwasaki T., et al. Identification and characterization of RRM-containing coactivator activator (CoAA) as TRBP-interacting protein, and its splice variant as a coactivator modulator (CoAM).
PMID: 17337438 by Yang Z., et al. Switched alternative splicing of oncogene CoAA during embryonal carcinoma stem cell differentiation.