RBL2 Antibodies

AND RBL2 ELISA kits, RBL2 Proteins

Many biological assays use antibodies to detect RBL2, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with RBL2 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop RBL2 antibodies...

We validate the specificity of these antibodies to RBL2 by testing them on tissues known to express RBL2 positively and negatively. Browse below to find the RBL2 antibody that suites your experiment. We have 4 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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RBL2 Infographic by Boster Bio

All RBL2 Products

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Product

Figures

Specificity

Applications

Price

Anti-p130 Rb2 RBL2 Antibody

Mouse

IHC, WB

$629
Cat # A02118
100uL

Rb2 p130 (RBL2) (NM_005611) Human Recombinant Protein

$1062
Cat # PROTQ08999
20 µg

Anti-Phospho-p130(T986) Rabbit Monoclonal Antibody

Human, Mouse

IP, WB

$370
Cat # P02118
100 μl/vial

Rb2 p130 (RBL2) (NM_005611) Human Over-expression Lysate

Human

$628
Cat # LS005934
100 µg

RBL2 Overview

Facts about Retinoblastoma-like protein 2.

RBL2 3D structure. Source: alphafold

Retinoblastoma-like protein 2 (RBL2)

Key regulator of entry into mobile division. Directly involved in heterochromatin formation by maintaining overall chromatin structure and, in particular, that of constitutive heterochromatin by stabilizing histone methylation.

Recruits and goals histone methyltransferases KMT5B and KMT5C, leading to epigenetic transcriptional repression. Probably functions as a transcription repressor by recruiting chromatin-modifying enzymes to promoters.

Gene Information

Human
Gene Name:	RBL2
Uniprot:	Q08999
Entrez:	5934

Family

Belongs to:

retinoblastoma protein (RB) family

Alternative Names

FLJ26459; P130; PRB2; Rb2; RBR-2; retinoblastoma-like 2 (p130); retinoblastoma-like protein 2,130 kDa retinoblastoma-associated protein; Retinoblastoma-related protein 2

Molecular Weight

Mass (kDA):
128.367 kDA

Genomic Context


Human

Location:	16q12.2
Sequence:	16; NC_000016.10 (53434471..53491648)

Subcellular Localizations

Nucleus.

Diseases

Retinoblastoma
Neoplasms
Malignant Neoplasms
Carcinoma
Cell Transformation, Neoplastic
Growth Arrest
Hyperplasia
Lung Neoplasms
Malignant Neoplasm Of Lung
Lymphoma
Malignant Paraganglionic Neoplasm
Neoplasm Metastasis
Mammary Neoplasms

Adenocarcinoma
Growth Retardation
Carcinogenesis
Malignant Squamous Cell Neoplasm
Ovarian Neoplasm
Malignant Neoplasm Of Breast
Non-small Cell Lung Carcinoma

Interacting Proteins

E2F4
LIN54
Pax3
PPP2CA
Sirt1

Vsx2

Pathways

Cell Cycle
Cell Proliferation
Cell Growth
S Phase
Cell Cycle Arrest
G1 Phase
Cell Differentiation
Pathogenesis
Methylation
Localization
Cell Death
Hyperphosphorylation
Senescence

Dna Replication
Cell Division
Dna Methylation
Oncogenesis
Mitosis
Proteolysis
Gene Silencing

PTMs

Phosphorylation
Methylation
Dephosphorylation
Acetylation

Demethylation
Deacetylation
Cleavage
Ubiquitination

Research Areas

Apoptosis
Cancer
Phospho-Specific
Tumor Suppressors

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/RBL2

References

PMID: 8253383 by Li Y., et al. The adenovirus E1A-associated 130-kD protein is encoded by a member of the retinoblastoma gene family and physically interacts with cyclins A and E.

PMID: 8253384 by Hannon G.J., et al. Isolation of the Rb-related p130 through its interaction with CDK2 and cyclins.