RASGRF2 Antibodies

AND RASGRF2 ELISA kits, RASGRF2 Proteins

Many biological assays use antibodies to detect RASGRF2, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with RASGRF2 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop RASGRF2 antibodies...

We validate the specificity of these antibodies to RASGRF2 by testing them on tissues known to express RASGRF2 positively and negatively. Browse below to find the RASGRF2 antibody that suites your experiment. We have 2 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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RASGRF2 Infographic by Boster Bio

All RASGRF2 Products

Product

Figures

Specificity

Applications

Price

RASGRF2 (NM_006909) Human Recombinant Protein

$1249
Cat # PROTO14827
20 µg

RASGRF2 (NM_006909) Human Over-expression Lysate

Human

$960
Cat # LS005924
100 µg

RASGRF2 Overview

Facts about Ras-specific guanine nucleotide-releasing factor 2.

RASGRF2 3D structure. Source: alphafold

Ras-specific guanine nucleotide-releasing factor 2 (RASGRF2)

Functions as a calcium-regulated nucleotide exchange factor activating both Ras and RAC1 through the exchange of bound GDP for GTP. Preferentially activates HRAS in vivo compared to RRAS according to their different kinds of prenylation.

Functions in synaptic plasticity by contributing to the induction of long term potentiation. .

Gene Information

Human
Gene Name:	RASGRF2
Uniprot:	O14827
Entrez:	5924

Family

Belongs to:

No superfamily

Alternative Names

DKFZp781H1715; GRF2RAS-GRF2; guanine nucleotide-releasing factor 2; Ras guanine nucleotide exchange factor 2; Ras protein-specific guanine nucleotide-releasing factor 2; Ras-GRF2; ras-specific guanine nucleotide-releasing factor 2

Molecular Weight

Mass (kDA):
140.764 kDA

Genomic Context


Human

Location:	5q14.1
Sequence:	5; NC_000005.10 (80960363..81230162)

Tissue Specificity

Widely expressed with higher expression in brain, followed by heart, lung, pancreas and kidney. Detected in placenta. Expressed in brain and lung (at protein level).

Subcellular Localizations

Cytoplasm. Cell membrane; Peripheral membrane protein. Endoplasmic reticulum membrane; Peripheral membrane protein. Translocates to membranes when activated. Found both at cell periphery and along the axon of neurons (By similarity).

Diseases

Malignant Neoplasms
Neoplasms
Nervousness
Cell Transformation, Neoplastic
Carcinogenesis
Malignant Neoplasm Of Pancreas
Mammary Neoplasms, Experimental
Leukemogenesis
Malignant Paraganglionic Neoplasm
Neoplasm Metastasis
Amnesia
Overlying Behavior
Melanoma

Thymus Neoplasms
Malignant Neoplasm Of Breast
Colonic Neoplasms
Malignant Tumor Of Colon
Immunologic Tolerance
Neoplasm Invasiveness
Malignant Neoplasm Of Lung

Pathways

Methylation
Localization
Brain Development
Aging
Dna Methylation
Proteolysis
Prenylation
Glucose Homeostasis
Reverse Transcription
System Development
Axon Guidance
Cell Cycle

Nervous System Development
Long-term Memory
Cell Growth
Cognition
Pathogenesis
Lymphocyte Proliferation

PTMs

Methylation
Demethylation
Farnesylation

Geranylgeranylation
Phosphorylation
Prenylation

Ubiquitination

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/RASGRF2

References

PMID: 10373510 by Anborgh P.H., et al. Ras-specific exchange factor GRF: oligomerization through its Dbl homology domain and calcium-dependent activation of Raf.

PMID: 11856323 by Lutchman M., et al. Dematin interacts with the Ras-guanine nucleotide exchange factor Ras-GRF2 and modulates mitogen-activated protein kinase pathways.