RASA4 Antibodies

AND RASA4 ELISA kits, RASA4 Proteins

Many biological assays use antibodies to detect RASA4, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with RASA4 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop RASA4 antibodies...

We validate the specificity of these antibodies to RASA4 by testing them on tissues known to express RASA4 positively and negatively. Browse below to find the RASA4 antibody that suites your experiment. We have 2 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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RASA4 Infographic by Boster Bio

All RASA4 Products

Product

Figures

Specificity

Applications

Price

Anti-RASA4 Antibody

Human, Mouse, Rat

$405
Cat # A09928
100ul

RASA4 (NM_006989) Human Over-expression Lysate

Human

$960
Cat # LS010156
100 µg

RASA4 Overview

Facts about Ras GTPase-activating protein 4.

RASA4 3D structure. Source: alphafold

Ras GTPase-activating protein 4 (RASA4)

Ca(2+)-dependent Ras GTPase-activating protein, that switches off the Ras-MAPK pathway following a stimulation that elevates intracellular calcium. Functions as an adaptor for Cdc42 and Rac1 during FcR-mediated phagocytosis.

Gene Information

Human
Gene Name:	RASA4
Uniprot:	O43374
Entrez:	10156

Family

Belongs to:

No superfamily

Alternative Names

Ca2+-promoted Ras inactivator; Calcium-promoted Ras inactivator; CAPRIGAPLKIAA0538RASA4B; FLJ59070; Putative Ras GTPase-activating protein 4B; ras GTPase-activating protein 4; RAS p21 protein activator 4MGC131890; RasGAP-activating-like protein 2

Molecular Weight

Mass (kDA):
90.458 kDA

Genomic Context


Human

Location:	7q22.1
Sequence:	7; NC_000007.14 (102579646..102616758, complement)

Tissue Specificity

Widely expressed.

Subcellular Localizations

Cytoplasm, cytosol. Cell membrane; Peripheral membrane protein. Localized to the cytosol as a result of its lack of phosphoinositide binding activity. Upon agonist-stimulated calcium mobilization, utilizes the C2A and C2B domains to associate with the plasma membrane.

Diseases

Malignant Neoplasms
Bacterial Infections
Coinfection
Neoplasms
Primary Effusion Lymphoma
Innate Immune Response
Lymphoma

B-cell Lymphomas
Cytogenetic Abnormality

Pathways

Localization
Transport
Ras Protein Signal Transduction
Cell Activation
Mitochondrion Transport Along Microtubule
Immune Response
Regulation Of Mast Cell Activation
Folic Acid Transport
Mast Cell Activation
Bmp Signaling Pathway
Er To Golgi Vesicle-mediated Transport
Cytokine Production
Phagocytosis

Carbon Dioxide Transport
Water Transport
Transforming Growth Factor Beta Receptor Signaling Pathway
Innate Immune Response
Cell Growth
Vesicle-mediated Transport
Nuclear Import

PTMs

Cleavage

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/RASA4

References

PMID: 11448776 by Lockyer P.J., et al. CAPRI regulates Ca(2+)-dependent inactivation of the Ras-MAPK pathway.