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- Table of Contents
Facts about DNA repair protein RAD51 homolog 3.
Part of this RAD21 paralog protein complexes BCDX2 and CX3 which act at different stages of this BRCA1-BRCA2-dependent HR pathway. Upon DNA damage, BCDX2 seems to act downstream of BRCA2 recruitment and upstream of RAD51 recruitment; CX3 seems to act downstream of RAD51 recruitment; both complexes bind predominantly to the intersection of the four duplex arms of the Holliday junction (HJ) and to junction of replication forks.
Human | |
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Gene Name: | RAD51C |
Uniprot: | O43502 |
Entrez: | 5889 |
Belongs to: |
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RecA family |
BROVCA3; DNA repair protein RAD51 homolog 3; FANCO; MGC104277; R51H3; RAD51 homolog C (S. cerevisiae); RAD51 homolog C; RAD51L2RAD51 (S. cerevisiae) homolog C; RAD51-like protein 2; yeast RAD51 homolog 3
Mass (kDA):
42.19 kDA
Human | |
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Location: | 17q22 |
Sequence: | 17; NC_000017.11 (58692140..58735611) |
Expressed in a variety of tissues, with highest expression in testis, heart muscle, spleen and prostate.
Nucleus. Cytoplasm. Cytoplasm, perinuclear region. Mitochondrion. DNA damage induces an increase in nuclear levels. Accumulates in DNA damage induced nuclear foci or RAD51C foci which is formed during the S or G2 phase of cell cycle. Accumulation at DNA lesions requires the presence of NBN/NBS1, ATM and RPA.
PMID: 9469824 by Dosanjh M.K., et al. Isolation and characterization of RAD51C, a new human member of the RAD51 family of related genes.
PMID: 11751635 by Masson J.Y., et al. Identification and purification of two distinct complexes containing the five RAD51 paralogs.