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DNA repair protein RAD50 Antibodies
AND RAD50 ELISA kits, DNA repair protein RAD50 Proteins
Many biological assays use antibodies to detect DNA repair protein RAD50, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with DNA repair protein RAD50 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop DNA repair protein RAD50 antibodies...
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RAD50 Infographic by Boster Bio
All RAD50 Products
Product
Figures
Specificity
Applications
Price
Human
ELISA, Flow Cytometry, IF, ICC, WB
$370
Cat # A00347-2
100 μg/vial
Cat # A00347-2
100 μg/vial
RAD50 Overview
Facts about DNA repair protein RAD50.
DNA repair protein RAD50 (RAD50)
Component of the MRN complex, which plays a central role in double-strand break (DSB) repair, DNA recombination, maintenance of telomere integrity and meiosis. The complex possesses single-strand endonuclease activity and double-strand- specific 3'-5' exonuclease activity, which are supplied by MRE11.
RAD50 could be asked to bind DNA ends and hold them in close proximity. This could facilitate searches for short or long regions of sequence homology in the recombining DNA templates, and may also stimulate the activity of DNA ligases or restrict the nuclease activity of MRE11 to prevent nucleolytic degradation past a given point (PubMed:11741547, PubMed:9590181, PubMed:9705271, PubMed:9651580).
Gene Information
| Human | |
|---|---|
| Gene Name: | RAD50 |
| Uniprot: | Q92878 |
| Entrez: | 10111 |
Family
| Belongs to: |
|---|
| SMC family |
Alternative Names
DNA repair protein RAD50; EC 3.6; EC 3.6.1.15; EC 3.6.3; EC 3.6.3.27; hRad50; NBSLD; RAD50 (S. cerevisiae) homolog; RAD50 homolog (S. cerevisiae); Rad50; RAD502; RAD50-2
Molecular Weight
Mass (kDA):
153.892 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 5q31.1 |
| Sequence: | 5; NC_000005.10 (132556977..132646349) |
Tissue Specificity
Expressed at very low level in most tissues, except in testis where it is expressed at higher level. Expressed in fibroblasts.
Subcellular Localizations
Nucleus. Chromosome, telomere. Chromosome. Localizes to discrete nuclear foci after treatment with genotoxic agents.
Diseases
- Malignant Neoplasms
- Neoplasms
- Nijmegen Breakage Syndrome
- Ataxia Telangiectasia
- Genomic Instability
- Malignant Neoplasm Of Breast
- Ataxia
- Mammary Neoplasms
- Chromosome Breakage
- Telangiectasis
- Cell Transformation, Neoplastic
- Leukemia
- Carcinoma
Interacting Proteins
- ATRX
- RAD17
Pathways
- Dna Repair
- Cell Cycle
- Double-strand Break Repair
- Dna Replication
- Meiosis
- Telomere Maintenance
- Recombinational Repair
- Localization
- S Phase
- Dna Damage Checkpoint
- Cell Cycle Checkpoint
- Cell Death
- Mismatch Repair
PTMs
- Phosphorylation
- Cleavage
- Acetylation
- Methylation
- Ubiquitination
Research Areas
- Breast Cancer
- DNA Repair
- Homologous Recombination
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/RAD50
bosterbio.com/bosterbio-gene-info-cards/RAD50
References
PMID: 8756642 by Dolganov G.M., et al. Human Rad50 is physically associated with human Mre11: identification of a conserved multiprotein complex implicated in recombinational DNA repair.
PMID: 10415333 by Kim K.K., et al. Molecular cloning and characterization of splice variants of human RAD50 gene.