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RAB8A Antibodies
AND RAB8A ELISA kits, RAB8A Proteins
Many biological assays use antibodies to detect RAB8A, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with RAB8A in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop RAB8A antibodies...
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RAB8A Infographic by Boster Bio
All RAB8A Products
Product
Figures
Specificity
Applications
Price
Human
IHC, WB
$370
Cat # PA2280
100 μg/vial
Cat # PA2280
100 μg/vial
Human, Mouse, Rat
Flow Cytometry, IF, IHC, ICC, WB
$370
Cat # M02180
100 μl/vial
Cat # M02180
100 μl/vial
RAB8A Overview
Facts about Ras-related protein Rab-8A.
Ras-related protein Rab-8A (RAB8A)
The small GTPases Rab are crucial regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an energetic GTP-bound form that's able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, motion, tethering and fusion.
This Rab is involved in polarized vesicular trafficking and neurotransmitter release. Together with RAB11A, RAB3IP, the exocyst complex, PARD3, PRKCI, ANXA2, CDC42 and DNMBP boosts transcytosis of PODXL into the apical membrane initiation sites (AMIS), apical surface formation and lumenogenesis (PubMed:20890297).
Gene Information
| Human | |
|---|---|
| Gene Name: | RAB8A |
| Uniprot: | P61006 |
| Entrez: | 4218 |
Family
| Belongs to: |
|---|
| small GTPase superfamily |
Alternative Names
mel transforming oncogene (derived from cell line NK14)- RAB8 homolog; mel transforming oncogene (derived from cell line NK14); MELras-associated protein RAB8; Oncogene c-mel; RAB8A, member RAS oncogene family; RAB8mel transforming oncogene (RAB8 homolog); ras-related protein Rab-8A
Molecular Weight
Mass (kDA):
23.668 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 19p13.11 |
| Sequence: | 19; NC_000019.10 (16111889..16134234) |
Subcellular Localizations
Cell membrane; Lipid-anchor; Cytoplasmic side. Golgi apparatus. Recycling endosome membrane. Cell projection, cilium. Cytoplasmic vesicle, phagosome. Cytoplasmic vesicle, phagosome membrane; Lipid-anchor; Cytoplasmic side. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole. Cytoplasm, cytoskeleton, cilium basal body. Midbody. Cytoplasm. Cytoplasm, cytoskeleton, cilium axoneme. Colocalizes with OPTN at the Golgi complex and in vesicular structures close to the plasma membrane (PubMed:15837803). In the GDP-bound form, present in the perinuclear region (PubMed:12221131)
Diseases
- Retinal Degeneration
- Bardet-biedl Syndrome
- Kidney Diseases
- Neoplasms
- Familial Aplasia Of The Vermis
- Tissue Adhesions
- Malignant Neoplasms
- Retinal Diseases
- Vesicular Stomatitis
- Stomatitis
- Retinitis Pigmentosa
Interacting Proteins
- LRRK2
- OCRL
- OPTN
- RAB3IP
- RABIF
- RILPL1
- RILPL2
Pathways
- Transport
- Localization
- Exocytosis
- Secretion
- Rna Interference
- Pathogenesis
- Endocytosis
- Cytokinesis
- Protein Transport
- Vesicle Transport
- Cell Migration
- Cell Division
- Cholesterol Efflux
PTMs
- Phosphorylation
- Geranylgeranylation
- Prenylation
- Cleavage
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/RAB8A
bosterbio.com/bosterbio-gene-info-cards/RAB8A
References
PMID: 8294494 by Zahraoui A., et al. A small rab GTPase is distributed in cytoplasmic vesicles in non polarized cells but colocalizes with the tight junction marker ZO-1 in polarized epithelial cells.
PMID: 1886711 by Nimmo E.R., et al. The MEL gene: a new member of the RAB/YPT class of RAS-related genes.