RAB2A Antibodies

Ras-related protein Rab-2A (RAB2A)

Required for protein transport from the endoplasmic reticulum to the Golgi complex. .

Gene Information

Human
Gene Name:	RAB2A
Uniprot:	P61019
Entrez:	5862

Family

Belongs to:
small GTPase superfamily

Alternative Names

RAB2A, member RAS oncogene family; RAB2RAB2, member RAS oncogene family; ras-related protein Rab-2A; small GTP binding protein RAB2A

Molecular Weight

Mass (kDA):
23.546 kDA

Genomic Context

Human
Location:	8q12.1-q12.2
Sequence:	8; NC_000008.11 (60516910..60623644)

Subcellular Localizations

Endoplasmic reticulum-Golgi intermediate compartment membrane; Lipid-anchor. Melanosome. Endoplasmic reticulum membrane; Lipid-anchor. Golgi apparatus membrane; Lipid-anchor. Identified by mass spectrometry in melanosome fractions from stage I to stage IV.

Diseases

• Mental Disorders
• Squamous Cell Neoplasms
• Malignant Neoplasms
• Malignant Vaginal Neoplasm
• Uterine Cervical Neoplasm
• Bipolar Disorder

• Malignant Tumor Of Cervix

Interacting Proteins

• BLZF1
• FAM114A1
• FAM71C
• GOLGA2
• ICA1

• STAMBPL1

Pathways

• Transport
• Ras Protein Signal Transduction
• Reverse Transcription
• Translation
• Carbon Dioxide Transport
• Water Transport
• Transforming Growth Factor Beta Receptor Signaling Pathway
• Mitochondrion Transport Along Microtubule
• Vesicle-mediated Transport

• Folic Acid Transport
• Er To Golgi Vesicle-mediated Transport
• Bmp Signaling Pathway

PTMs

• Acetylation

• Lipoprotein

• Prenylation

Research Areas

• Signal Transduction

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/RAB2A

Best Uses Of The RAB2A Marker

The Anti-Ras-related protein Rab2A Marker is a highly sensitive marker used in cellular and molecular biology. We will be discussing the types, applications, price, availability, and pricing of this marker in this article. You can then make a decision based on your research. Read on to learn more. We hope that you find this information useful.

Anti-Ras-related protein Rab2A Marker

Boster Bio's Anti Raas related protein Rab2A markers are designed to detect the presence of this vital membrane trafficking actor. The product's catalog number is A06007 and it is tested in WB applications. It is highly effective at detecting this specific protein and has excellent Cross-Reactivity with Human, Mouse,, and Rat.

Applications

RAB2A, which is a highly homologous mammalian peptide, is normally found in the Golgi. Its functions include Golgi to-ER trafficking and stacking as well as secretion. In the current study, RAB2A silencing did not affect the secretion of soluble MMPs or their synthesis. It also did nothing to alter the levels or MT1MMP.

RAB2a regulates the TGN's granule maturation process and cargo sorting. It binds Noc2, which on immature Granules is bound to Rab27a. The mature granules dissociate from Rab2a. This suggests that Noc2 phosphorylation is necessary for its activity. Further, RAB2A is involved in the degradation of lipids at the endosomal membrane.

The RAB2A marker can be a powerful determinant of cancer-cell proliferation and metastasis. The elevated expression of RAB2A is a strong predictor of metastatic recurrence in human BC patients. Rab2A has been evolutionarily conserved at Q58 suggesting that it could function similarly in mammalian Rab2.

There are many suppliers that offer the RAB2A mark. It is a synthetic peptide derived from the RAB2A gene and belongs to the Small GTPase (Rab) family. It contains 212 amin acids and is used in diagnostics as well as cytology and immunoassays. It is not available in the market yet, but the RAB2A marker can be obtained from multiple sources.

A number of human cancers have been shown to increase the expression of the Rab2A gene. When expressed in human BCSCs, Rab2A overexpression increases tumorigenicity and expands BCSCs. GTPase activity was reduced by the cancer-derived RAB2AQ58H mutation. Immunoblot confirmed the amplification of Rab2A genes. Overexpression of Rab2A led to an increase in CD24-CD44+ HMLE cells. It also saved Pin1 and KD phenotypes from HMLE cell lines. Furthermore, shRNA-transfected HMLE-transfected cells overexpressed Rab2A which increased the formation of mammospheres both in control and shRNA treatment HMLE mice.

RAB2A is also present in low-litter and spermatozoa. It is also associated with the production of cytochrome b-c1 complex subunits. The expression of these proteins regulates AQN-3 (UQCRC1) and RAB2A (RAB2A). This gene is essential to enable spermatozoa survive in low-litter situations. It is also important in determining the size of a litter.

Availability

Boster Bio stocks antibodies to Rab GTPases from several suppliers. Boster Bio's A06007 catalog contains the RAB2A marker. It reacts with Humans, Mouses, and Rats. This antibody can also identify other proteins. It is capable of detecting Rab GTPases. As a result, it can assist in identifying the exact target protein.

RAB-2 activity is required to mature DCVs. This prevents them from entering late endosomes. This marker helps identify mutant cells expressing RAB-2 gene expression. It can cross-react also with RAB2A proteins. Boster Bio offers the RAB2A mark, which helps researchers understand how RAB-2 plays a role in DCV maturation.

The RAB2A protein is expressed in neuronal cells and neurons. However, it prefers early Golgi Cisternae. In experiments, fourteen neuronal Golgi structures had an average of 3.3 +/0.9 immunogold labels on their cis side, 1.5+-0.4 in their medial Golgi, or 1.0+/0.5 on their trans side. RAB-2 immunogold labels were also observed around the Golgi's vesicular structures. It was not detected in the nu415 deletion mutant.

A recent proteomic analysis of highly purified synaptic vesicles found that RAB2A is co-purified with multiple other Rab GTPases. Multiple Rabs may be required to regulate endocytosis of SVs, as this suggests. These mutations are also known as to inhibit alanine transfer in neurons. RAB2A might also disrupt the function and endocytosis of the receptor.

Price

Boster Bio has the RAB2A indicator for $67/pair. RAB2A binds tightly to the ERA Glycoprotein unlike other biomarkers. Biolayer interferometry is used to measure binding affinities and association and dissociation rate. Recent research has shown RAB1's binding ability is higher than RAB2.