Ras-related protein Rab-1A (RAB1A)

The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that's able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, motion, tethering and fusion.

RAB1A regulates vesicular protein transport from the endoplasmic reticulum (ER) to the Golgi compartment and to the cell surface, and plays a part in IL-8 and growth hormone secretion. Regulates the level of CASR present at the cell membrane.