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- Table of Contents
28 Citations 12 Q&As
2 Citations 7 Q&As
Facts about Pentraxin-related protein PTX3.
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Human | |
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Gene Name: | PTX3 |
Uniprot: | P26022 |
Entrez: | 5806 |
Belongs to: |
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No superfamily |
alpha-induced protein 5; pentaxin-related gene, rapidly induced by IL-1 beta, tumor necrosis factor; Pentaxin-related protein PTX3; Pentraxin 3; pentraxin 3, long; pentraxin-3; pentraxin-related gene, rapidly induced by IL-1 beta; pentraxin-related protein PTX3; PTX3; TNF alpha-induced protein 5; TNFAIP5; TSG14; TSG-14; TSG-14pentaxin-related gene, rapidly induced by IL-1 beta; Tumor necrosis factor alpha-induced protein 5; tumor necrosis factor, alpha-induced protein 5; Tumor necrosis factor-inducible gene 14 protein; tumor necrosis factor-inducible protein TSG-14
Mass (kDA):
41.976 kDA
Human | |
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Location: | 3q25.32 |
Sequence: | 3; NC_000003.12 (157436850..157443633) |
Secreted.
This article will focus on the PTX3 biomarker. It is a new marker that is able to predict the severity of disease. This marker can also predict the severity of bloodstream infection and Septic shock, aswell in the response to treatment. Boster will also provide guidelines for interpreting the results of this marker. In addition, you'll be taught more about how you can share your findings with colleagues and earn credits for the product.
PTX3 is a brand new biomarker that can be used to determine the severity of the disease in many situations. Numerous studies have shown that PTX3 is linked to renal failure, coagulation dysfunction and cardiovascular disease. The PTX3 levels are also associated with severity parameters like platelet count, d–dimer creatinine, and MAP. PTX3 was also shown to be a reliable predictor of mortality in sepsis.
Clinical studies of PTX3 have shown that it is significantly higher among failing HF patients than in the healthy controls. The PTX3 levels of HF patients of the most severe NYHA class were significantly higher than in the control group. The study also found that PTX3 levels were significantly higher in patients suitable for a transplant. This is an important finding as it suggests a potential role in the role of PTX3 in cardiac failure.
PTX3 is being investigated for its possible role in DR. Researchers have discovered a strong connection between PTX3 and DR. It is linked to a decrease in complement regulator factor H (CFH), activity. However it is necessary to conduct more research to determine whether PTX3 plays a role in the pathogenesis of DR.
The levels of PTX3 were elevated in cases of widespread inflammation. PTX3 is produced mostly by activated endothelial and dendritic cell populations. Additionally, PTX3 inhibits P-selectin-dependent adhesion in living. The presence of PTX3 in sputum specimens could be an important indicator of the severity of disease in the infiltrates of inflammation.
The study also demonstrated an association between PTX3 levels as well as neonatal outcomes and PTX3 levels. In fact, PTX3 levels and scores for APGAR were related to worse neonatal outcomes. More respiratory distress syndrome cases and longer stay in the NICU were also associated to a lower APGAR score. These associations could have significant implications in the treatment of neonatal Sepsis.
Although we are still not sure of the role of PTX3 atherosclerosis, it has been suggested that PTX3 could have an impact on the inflammation of the vascular system as well as plaque formation. The presence of PTX3 could be a biomarker of hypertension and a target for therapeutic intervention. More research is required to confirm the role of PTX3 as biomarker to determine the severity of disease.
A new study has shown that a biomarker for PTX3 in newborns can accurately predict bloodstream infections. The study was published in the journal Science Translational Medicine, examined the relationship between PTX3 levels and neonatal outcomes. These included lower APGAR scores as well as clinical sepsis as well as the length of NICU stay. Despite the findings of the study, it's not certain if the new biomarker will prove useful in the clinical setting.
PTX3 is a member of the Pentraxin superfamily. The protein regulates inflammation and regulates complement activation. It also aids in the recognition of pathogens by myeloid cells. PTX3 levels are associated with severity of sepsis, patient survival, and response to therapy. In addition it predicts the likelihood that patients will respond to specific treatment regimens or whether they will recover.
PTX3 interacts with specific microorganisms. It binds to a variety of bacteria, fungi, and viruses. Ma and her coworkers have discovered that PTX3 interacts with the mannose-binding lectin MBL. This interaction enhances the rate of phagocytosis for Candida albicans. While this interaction doesn't directly affect the fate of cells that die, it does increase the rate of phagocytosis by neutrophils.
A new biomarker has been discovered for COVID-19. Boster Bio PTX3, a new COVID-19 marker, integrates activation of myeloid, endothelial, as well as complement cells as well as cytokine generation. This research has significant clinical implications for management and prognosis. Science Translational Medicine published the findings of the researchers.
A new study has found that patients who receive intensive chemotherapy for breast cancer are at risk of an increased risk of developing Septicaemia and septicoma due to the biomarker PTX3. The study also discovered that a patient's level C-reactive protein (CRP) is correlated with pentraxin 3 (PTX3). This could be the best method to gauge the severity of a patient’s condition according to research.
The Boster Bio PTX3 marker was found to have a strong correlation with bacteriaemia, septic shock and CRP. The study found that elevated PTX3 levels within the first 48 hours were a sign of septic shock or bacteremia. Also the increase in CRP on Day 0 was a predictor of. Researchers used repeated measure analyses and found that those with a higher PTX3 level were more likely to enter Septic shock.
The PTX3 protein is present in a variety cells, including DCs and myeloid cells. While DCs and immune cells produce PTX3, neutrophils are the most frequent source. Furthermore, neutrophils are believed to be the primary source of ficolin-1. The Boster Bio PTX3 marker is a predictor of septic shock in patients suffering from mild LRTI.
C-reactive proteins are a close cousin to PTX3 however, the two proteins differ in their amino acid sequences. The statistically significant difference between the markers at day zero wasn't evident or were there any differences in gender, age or co-morbidities. There is also a weak correlation between the PTX3 markers and PTX3 levels. The results are encouraging and warrant further research.
Recent research suggests that the PTX3 protein plays an essential role in the immune system's innate system and is a major biomarker of treatment response. It interacts with complement components, such as P-selectin, which regulates neutrophil recruitment and regulate the activity of complement. Furthermore it has been implicated in the prevention of certain diseases that cause infection. These pathways are subject to further study by PTX3.
The PTX3 gene can be expressed on many cell types, including myeloid ones. The expression of this gene was found to increase in respiratory tract epithelial cells during the response to the SARS-CoV-2 infection. It also increased rapidly in response the recognition of microbial species and inflammation. It has also been associated with mortality and cardiovascular disease in sepsis. Further research is required to determine whether PTX3 is a biomarker of the response to therapy.
The PTX3 gene has been linked to haemostasis and fibrinolysis, making it a useful biomarker for the classification of patients suffering from coagulation problems. The study found that PTX3 levels are elevated during severe sepsis, and even higher in septic shock. Furthermore, impaired normalization and reduced PTX3 levels were associated with multi-organ failure and an increased risk of death.
Recent research has demonstrated that the BosterBio PTX3 marker for respiratory infections is highly sensitive and precise. It also correlates with the clinical outcomes for newborns suffering from a lower respiratory tract infection. Further it is known that the PTX3 gene is associated with the higher prevalence of bacterial infections. This includes respiratory distress syndrome. It also relates to the length of stay in the NICU.
In addition to its role in phagocytosis PTX3 is also an important complement sensor. PTX3 is a microbial receptor that binds to specific patterns. It recruits the complement component C1q to enhance the rate of phagocytosis of an cells that are dying. Additionally, PTX3 is known to interact with the lectin pathway. The interaction between PTX3 and MBL results in an increase in phagocytosis by neutrophils of Candida albicans.
PMID: 1429570 by Breviario F., et al. Interleukin-1-inducible genes in endothelial cells. Cloning of a new gene related to C-reactive protein and serum amyloid P component.
PMID: 8131794 by Introna M., et al. IL-1 inducible genes in human umbilical vein endothelial cells.
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