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PSMD12 Antibodies
AND PSMD12 ELISA kits, PSMD12 Proteins
Many biological assays use antibodies to detect PSMD12, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with PSMD12 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop PSMD12 antibodies...
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PSMD12 Infographic by Boster Bio
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PSMD12 Overview
Facts about 26S proteasome non-ATPase regulatory subunit 12.
26S proteasome non-ATPase regulatory subunit 12 (PSMD12)
Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required.
Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair. .
Gene Information
| Human | |
|---|---|
| Gene Name: | PSMD12 |
| Uniprot: | O00232 |
| Entrez: | 5718 |
Family
| Belongs to: |
|---|
| proteasome subunit p55 family |
Alternative Names
26S proteasome non-ATPase regulatory subunit 12; 26S proteasome regulatory subunit p55; 26S proteasome regulatory subunit RPN5; MGC75406; p55; proteasome (prosome, macropain) 26S subunit, non-ATPase, 12; Rpn5
Molecular Weight
Mass (kDA):
52.904 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 17q24.2 |
| Sequence: | 17; NC_000017.11 (67337916..67366598, complement) |
Diseases
- Liver Diseases
- Chronic Infectious Disease
- Liver Carcinoma
- Steatohepatitis
- Hepatitis
- Cholecystolithiasis
- Hepatitis B
- Diabetes Mellitus
- Hepatitis B, Chronic
- Carcinoma
- Insulin Resistance
Interacting Proteins
- PSMD4
Pathways
- Programmed Cell Death
- Cell Death
- Regulation Of Gene Expression
PTMs
- Acetylation
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/PSMD12
bosterbio.com/bosterbio-gene-info-cards/PSMD12
References
PMID: 9426256 by Saito A., et al. cDNA cloning and functional analysis of p44.5 and p55, two regulatory subunits of the 26S proteasome.
PMID: 1317798 by Kanayama H.O., et al. Demonstration that a human 26S proteolytic complex consists of a proteasome and multiple associated protein components and hydrolyzes ATP and ubiquitin-ligated proteins by closely linked mechanisms.