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- Table of Contents
6 Citations 15 Q&As
4 Citations 5 Q&As
1 Citations 17 Q&As
Facts about Periostin.
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Human | |
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Gene Name: | POSTN |
Uniprot: | Q15063 |
Entrez: | 10631 |
Belongs to: |
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No superfamily |
Fasciclin I-like; MGC119510; MGC119511; OSF2; OSF-2; OSF-2osteoblast specific factor 2 (fasciclin I-like); OSF2periodontal ligament-specific periostin; Osteoblast-specific factor 2; PDLPOSTN; periostin isoform thy2; periostin isoform thy4; periostin isoform thy6; periostin isoform thy8; Periostin; periostin, osteoblast specific factor; PNRP11-412K4.1; POSTN; TRIF52
Mass (kDA):
93.314 kDA
Human | |
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Location: | 13q13.3 |
Sequence: | 13; NC_000013.11 (37562582..37598844, complement) |
Widely expressed with highest levels in aorta, stomach, lower gastrointestinal tract, placenta, uterus, thyroid tissue and breast. Up-regulated in epithelial ovarian tumors. Not expressed in normal ovaries. Also highly expressed at the tumor periphery of lung carcinoma tissue but not within the tumor. Overexpressed in breast cancers.
Golgi apparatus. Secreted. Secreted, extracellular space, extracellular matrix. Colocalizes with BMP1 in the Golgi.
PMID: 8363580 by Takeshita S., et al. Osteoblast-specific factor 2: cloning of a putative bone adhesion protein with homology with the insect protein fasciclin I.
PMID: 12235007 by Gillan L., et al. Periostin secreted by epithelial ovarian carcinoma is a ligand for alpha(V)beta(3) and alpha(V)beta(5) integrins and promotes cell motility.
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