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POLR3G Antibodies
AND POLR3G ELISA kits, POLR3G Proteins
Many biological assays use antibodies to detect POLR3G, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with POLR3G in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop POLR3G antibodies...
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POLR3G Overview
Facts about DNA-directed RNA polymerase III subunit RPC7.
DNA-directed RNA polymerase III subunit RPC7 (POLR3G)
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific peripheric component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs (PubMed:20154270).
May direct with other members of the RPC3/POLR3C-RPC6/POLR3F-RPC7/POLR3G subcomplex RNA Pol III binding to the TFIIIB-DNA complex via the interactions between TFIIIB and POLR3F. May be involved either in the recruitment and stabilization of the subcomplex within RNA polymerase III, or in stimulating catalytic functions of different subunits during initiation.
Gene Information
| Human | |
|---|---|
| Gene Name: | POLR3G |
| Uniprot: | O15318 |
| Entrez: | 10622 |
Family
| Belongs to: |
|---|
| eukaryotic RPC7 RNA polymerase subunit family |
Alternative Names
DNA-directed RNA polymerase III 32 kDa polypeptide; DNA-directed RNA polymerase III subunit G; DNA-directed RNA polymerase III subunit RPC7; polymerase (RNA) III (DNA directed) polypeptide G (32kD); RNA polymerase III 32 kDa subunit; RNA polymerase III subunit C7; RPC32RPC7
Molecular Weight
Mass (kDA):
25.914 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 5q14.3 |
| Sequence: | 5; NC_000005.10 (90473929..90514557) |
Tissue Specificity
Barely detectable in differentiated tissues. Expressed in embryonic stem cells and in other dividing cells, such as some tumor cell lines.
Subcellular Localizations
Nucleus. Cytoplasm. Excluded from nucleoli (PubMed:21898682). In zygotes and the 2-cell stage embryos, mainly in the cytoplasm. Starts to localize to the nucleus in the 8-16 cell stage embryo and early blastocysts (By similarity).
Diseases
- Epilepsy
- Haploinsufficiency
- Nervousness
- Febrile Convulsions
- Muscle Hypotonia
Interacting Proteins
- POLR3C
- POLR3F
Pathways
- Transport
PTMs
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/POLR3G
bosterbio.com/bosterbio-gene-info-cards/POLR3G
References
PMID: 9171375 by Wang Z., et al. Three human RNA polymerase III-specific subunits form a subcomplex with a selective function in specific transcription initiation.
PMID: 12391170 by Hu P., et al. Characterization of human RNA polymerase III identifies orthologues for Saccharomyces cerevisiae RNA polymerase III subunits.