Plexin-A1 Antibodies

Plexin-A1 (PLXNA1)

Coreceptor for SEMA3A, SEMA3C, SEMA3F and SEMA6D.

Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton.

Plays a role in axon guidance, invasive growth and cell migration. Class 3 semaphorins bind to a complex composed of a neuropilin and a plexin.

Gene Information

Human
Gene Name:	PLXNA1
Uniprot:	Q9UIW2
Entrez:	5361

Family

Belongs to:
plexin family

Alternative Names

NOV; NOVP; Plexin A1; PLEXIN-A1; PLXN1; PLXNA1

Molecular Weight

Mass (kDA):
211.067 kDA

Genomic Context

Human
Location:	3q21.3
Sequence:	3; NC_000003.12 (126983259..127037392)

Tissue Specificity

Detected in fetal brain, lung, liver and kidney.

Subcellular Localizations

Cell membrane; Single-pass type I membrane protein.

Diseases

• Nervousness
• Malignant Neoplasms
• Neoplasms
• Tumor Angiogenesis
• Tissue Adhesions
• Carcinoma
• Pathologic Neovascularization
• Malignant Paraganglionic Neoplasm
• Malignant Neoplasm Of Breast
• Glioma
• Mammary Neoplasms
• Cell Invasion
• Stomach Neoplasms

• Neoplasm Metastasis
• Neoplasm Invasiveness
• Adenocarcinoma
• Autoimmune Diseases
• Tumor Progression
• Pancreatic Neoplasm
• Malignant Neoplasm Of Pancreas

Pathways

• Axon Guidance
• Cell Migration
• Angiogenesis
• Cell Adhesion
• Chemotaxis
• Cell Proliferation
• Rna Interference
• Transport
• Reverse Transcription
• Induction Of Apoptosis
• Nerve Development
• Facial Nerve Development
• Cytokine Production

• Cell Death
• Innervation
• Cell Activation
• T Cell Activation
• Neurogenesis
• Ossification
• Cartilage Development

PTMs

• Phosphorylation

• Cleavage

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/PLXNA1

Boster Bio - Best Uses Of The PLXNA1 Marker

Are you interested to learn more about the PLXNA1Marker? This article will provide information about Boster and the history of the antigen. We'll also discuss the uses of this marker in various biological settings. Read on for more information! Click the links below to learn more about Boster’s research. This article is written for scientists, researchers, and the general public.

Anti-Plexin A1 PLXNA1 Marker

The Anti-Plexin A1 ELISA kit from Boster Bio can be used for detection of human Plexin A1. It is tested for its ability to detect human Plexin A1 in ICC, WB, and flow cytometry. This kit was able to react with human, mouse, and rat cells. The Technical Information section of Boster Bio's website lists the dilutions used.

Plexin A1 (200 kDa) is a transmembrane type I transmembrane proteins. It belongs to the family of Semaphorin signal transducers. It regulates many processes in cells, including neuronal and axon development, as well as anti-angiogenesis. This marker is highly specific and allows for precise analysis of biological processes.

Several suppliers offer Anti-Plexin A1 ELISA kits. The antibody is a monoclonal antibody against PLXNA1, a protein found in many cell types. It is one member of a family that includes nine other proteins. It is involved in the signaling growth factors. It is activated in growth cones and causes destabilization of microtubules and actin. The protein has been shown to be non-toxic in hUC-MSCs up to 2 mg/mL and 3 mg/mL.

The LISSV-related virus infection resulted in a reduction in the expression levels of PLXNA4 (and other neuronal genes). LISSV, a Semaphorin 3A-dependent PLEXNA4 ligand, activated SEMA3A and FYN, a downstream signaling molecule. This study indicates that PLXNA4-PLXNA4-mediated FYN activation is important in hUC-MSC neuronal differentiation.

PLXNA1 Marker's history

The PLXNA1 genome is present in humans and mice. It is involved with the development of the neuroendocrine axis and is responsible for organizing olfactory-associated Axonal tracts. It also guides GnRH–synthesizing neural cells. Further studies are needed to determine its function and its role in the development of human corticospinal systems.

There are two possible explanations for the regulation PLXNA1 or MAPK signalling pathways. One is that miR134 may be involved with the development of ESCC. Effective inhibitors of MAPK signalling pathways are effective at inhibiting tumour growth. MiR-134 also inhibits PLXNA1 transcription. ESCC may also be a target.

Uses for the PLXNA1Marker

PLXNA1 is a protein that is expressed by the prostate gland. It plays a vital role in prostate cell proliferation, invasion, and metastasis. High levels of this protein in prostate cancer cells are associated with a higher risk of malignancy. Studies using this protein are important in early detection and risk assessment for prostate cancer. The protein is also used to make pharmaceuticals for the treatment and prevention of prostate cancer.

In the present invention, the PLXNA1 biomarker was identified as an independent risk factor for prostate cancer. This marker could differentiate between high-risk or low-risk prostate carcinoma. This marker is useful for screening and detection prostate cancer, and other high-risk malignancies. The present invention can be classified as a diagnostic, therapeutic, or biomarker. Among these, PLXNA1 represents a new and important molecule within the field of Biomedicine.

Metastatic prostate cancer is a common place where PLXNA1 expression is high. It is also related with overall survival after radical surgical and non-metastatic forms of prostate cancer. The present inventors studied whether an increase in PLXNA1 copy number correlates with higher malignancy. Further, they examined whether the PLXNA1 genome copy number is directly linked to prostate cancer recurrence. The PLXNA1 gene number could be used to assess prostate cancer malignancy.

The protein is also used to grow cells in addition the previously mentioned uses. Overexpression PLXNA1 is a significant factor in cell proliferation, invasion and migration. The invasion and migration experiments were performed on prostate cancer cells that were grown in 6-well plates. They were transfected with Lipofectamine 2000, which contains 4 ug of the plasmid. The cells were cultured in the exact same way as in 1.1 following transfection.