Placenta growth factor Antibodies

Placenta growth factor (PGF)

Growth factor active in angiogenesis and endothelial cell growth, stimulating their proliferation and migration. It binds to the receptor FLT1/VEGFR-1.

Isoform PlGF-2 binds NRP1/neuropilin-1 and NRP2/neuropilin-2 at a heparin-dependent Method. Also promotes cell tumor development.

Gene Information

Human
Gene Name:	PGF
Uniprot:	P49763
Entrez:	5228

Family

Belongs to:
PDGF/VEGF growth factor family

Alternative Names

D12S1900; PGF; PGFL; placenta growth factor; placental growth factor; placental growth factor, vascular endothelial growth factor-related protein; PlGF; PlGF-2; PLGFplacental growth factor-like; SHGC-10760

Molecular Weight

Mass (kDA):
24.789 kDA

Genomic Context

Human
Location:	14q24.3
Sequence:	14; NC_000014.9 (74941830..74955764, complement)

Tissue Specificity

While the three isoforms are present in most placental tissues, PlGF-2 is specific to early (8 week) placenta and only PlGF-1 is found in the colon and mammary carcinomas.

Subcellular Localizations

Secreted. The three isoforms are secreted but PlGF-2 appears to remain cell attached unless released by heparin.

Diseases

• Endometrial Polyp
• Inflammation
• Pathologic Vasoconstriction
• Hypertensive Disease
• Mycoplasma Pneumonia
• Malignant Neoplasms
• Neoplasms
• Pituitary Diseases
• Cattle Diseases
• Diabetes Mellitus
• Hypoxia
• Polyendocrinopathies, Autoimmune
• Premature Obstetric Labor

• Ischemia
• Tumor Angiogenesis
• Flushing
• Pain
• Pathological Dilatation
• Pseudopregnancy
• Stenosis

Interacting Proteins

• FLT1

Pathways

• Estrus
• Ovulation
• Secretion
• Luteolysis
• Insemination
• Parturition
• Excretion
• Transport
• Pathogenesis
• Vasoconstriction
• Diestrus
• Angiogenesis
• Progesterone Secretion

• Mating
• Fertilization
• Prostaglandin Secretion
• Platelet Aggregation
• Localization
• Vasodilation
• Inflammatory Response

PTMs

• Phosphorylation
• Oxidation
• Cleavage
• Reduction
• Dephosphorylation
• Nitration
• Glycosylation

• Acetylation
• Ribosylation
• Myristoylation
• Sulphation
• Prenylation
• Iodination
• Methylation

Research Areas

• Angiogenesis

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/PGF

Boster Bio Review - Best Uses Of The PGF Marker

If you're an educator, you're probably thinking about Boster Bio's Anti-Macrosialin CD68 Antibody. This Boster Bio review will give you a an description of the PGF Marker and its applications. Boster Bio PDFs can be shared with educators by students as long as they provide a link to the source.

Boster Bio

Boster Bio ELISA Kits detect a variety hormones, small molecules and the oxidative stress. They can also detect cytokines (DNA damage) and granzyme B (cytokines). Each kit includes enough reagents to perform 96 tests and is tested across a variety of samples. These kits can also detect the presence of IL-6 and IL-8, as well as EGF and IL-10. EGF.

Boster Bio Anti-Macrosialin CD68 Antibody

The Boster Bio Anti-Macrosialn CD68 Monoclonal is designed to detect Macrosialin in tissues samples. It has been tested in IHC-P protocols for both human and mouse samples. Boster Bio Anti Macrosialin CD68 Antibody reacts to Human, Rat, and Mouse. Boster Bio Anti Macrosialin CD68 Antibody makes use of PGF marker to identify this specific protein within cell samples.

Macrosialin CD68 is a highly glycosylated, 110-kDa protein that is expressed on tissue macrophages and other cells. The PGF marker is efficient in detecting Macrosialin as well as other markers in macrophage lineage. This protein is also present on dendritic cells as well as tissue macrophages. It is component of the PGF receptor complex. It is involved in intracellular lysosomal metabolism and extracellular cell-cell interactions.

Macrosialin CD68 plays a significant marker of the immune system. It binds to many organ-specific lectins and tissue-specific ones. This allows macrophage subsets of macrophages to be directed towards a particular location. In addition to this Macrosialin CD68 is able to crawl over other cells and even substrates. This marker is quickly returned to the Lysosomes.

The anti-CD68 anti-mAb isn't effective in IHC to establish the definitive identification of Macrosialin in synovial tissues. Because it overlaps with FB and PGM1, it is not suitable for use on synovial tissues. This antibody is unable to detect the marker and could not be effective in the treatment of osteoarthritis.