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- Table of Contents
Facts about Profilin-1.
By binding to PIP2, it inhibits the formation of IP3 and DG. Inhibits androgen receptor (AR) and HTT aggregation and binding of G-actin is essential for its inhibition of AR.
Human | |
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Gene Name: | PFN1 |
Uniprot: | P07737 |
Entrez: | 5216 |
Belongs to: |
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profilin family |
PFN1; PROF1; Profilin 1; Profilin I; profilin-1
Mass (kDA):
15.054 kDA
Human | |
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Location: | 17p13.2 |
Sequence: | 17; NC_000017.11 (4945652..4948530, complement) |
Expressed in epididymis (at protein level).
Cytoplasm, cytoskeleton.
PMID: 3356709 by Kwiatkowski D.J., et al. Human profilin. Molecular cloning, sequence comparison, and chromosomal analysis.
PMID: 20736409 by Li J., et al. Systematic mapping and functional analysis of a family of human epididymal secretory sperm-located proteins.