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- Table of Contents
Facts about Phosphatidylethanolamine-binding protein 1.
Serine protease inhibitor which inhibits thrombin, neuropsin and chymotrypsin but not trypsin, tissue type plasminogen activator and elastase (By similarity). Inhibits the kinase activity of RAF1 by inhibiting its activation and by dissociating the RAF1/MEK complex and acting as a competitive inhibitor of MEK phosphorylation.
Human | |
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Gene Name: | PEBP1 |
Uniprot: | P30086 |
Entrez: | 5037 |
Belongs to: |
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phosphatidylethanolamine-binding protein family |
HCNP; HCNPpp; hippocampal cholinergic neurostimulating peptide; Neuropolypeptide h3; PBP; PBPPEBP-1; PEBP1; PEBP-1; PEBPHCNPpp; phosphatidylethanolamine binding protein 1; phosphatidylethanolamine-binding protein 1; prostatic binding protein; Prostatic-binding protein; Raf kinase inhibitory protein; RKIP; RKIPRaf kinase inhibitor protein
Mass (kDA):
21.057 kDA
Human | |
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Location: | 12q24.23 |
Sequence: | 12; NC_000012.12 (118136124..118145584) |
Cytoplasm.
PMID: 8144042 by Hori N., et al. A human cDNA sequence homologue of bovine phosphatidylethanolamine- binding protein.
PMID: 7637590 by Tohdoh N., et al. Sequence homology of rat and human HCNP precursor proteins, bovine phosphatidylethanolamine-binding protein and rat 23-kDa protein associated with the opioid-binding protein.