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PDCD6 Antibodies
AND PDCD6 ELISA kits, PDCD6 Proteins
Many biological assays use antibodies to detect PDCD6, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with PDCD6 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop PDCD6 antibodies...
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PDCD6 Overview
Facts about Programmed cell death protein 6.
Programmed cell death protein 6 (PDCD6)
Calcium sensor that plays an integral role in processes like endoplasmic reticulum (ER)-Golgi vesicular transport, endosomal biogenesis or membrane repair. Acts as an adapter that bridges unrelated proteins or stabilizes weak protein-protein complexes in response to calcium: calcium-binding triggers exposure of apolar surface, promoting interaction with unique sets of proteins owing to 3 distinct hydrophobic pockets, leading to translocation to membranes (PubMed:20691033, PubMed:25667979).
Involved in ER-Golgi transport by encouraging the association between PDCD6IP and TSG101, thereby bridging together the ESCRT- III and ESCRT-I complexes (PubMed:19520058). In response to cytosolic calcium increase, the heterodimer formed with PEF1 interacts with, and bridges together the BCR(KLHL12) complicated and SEC31 (SEC31A or SEC31B), boosting monoubiquitination of SEC31 and subsequent collagen export, which is required for neural crest specification (PubMed:27716508).
Gene Information
| Human | |
|---|---|
| Gene Name: | PDCD6 |
| Uniprot: | O75340 |
| Entrez: | 10016 |
Family
| Belongs to: |
|---|
| No superfamily |
Alternative Names
ALG2; ALG-2; Apoptosis-linked gene 2 protein; apoptosis-linked gene-2; FLJ46208; MGC111017; MGC119050; MGC9123; PDCD6; PEF1B; Probable calcium-binding protein ALG-2; programmed cell death 6; programmed cell death protein 6
Molecular Weight
Mass (kDA):
21.868 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 5p15.33 |
| Sequence: | 5; NC_000005.10 (271621..314974) |
Subcellular Localizations
Endoplasmic reticulum membrane; Peripheral membrane protein. Cytoplasmic vesicle, COPII-coated vesicle membrane. Cytoplasm. Nucleus. Endosome. Interaction with RBM22 induces relocalization from the cytoplasm to the nucleus (PubMed:17045351). Translocated from the cytoplasm to the nucleus after heat shock cell treatment. Accumulates in cytoplasmic vesicle-like organelles after heat shock treatment, which may represent stress granules (PubMed:21122810). In response to calcium increase, relocates from cytoplasm to COPII vesicle coat (PubMed:27716508). Localizes to endoplasmic reticulum exit site
Diseases
- Malignant Neoplasms
- Neoplasms
- Lung Neoplasms
- Ovarian Neoplasm
- Malignant Neoplasm Of Lung
- Malignant Neoplasm Of Ovary
- Cell Invasion
- Arteriosclerosis
- Alzheimer's Disease
- Alzheimer Disease, Familial
- Stomach Neoplasms
- Neoplasm Metastasis
- Melanoma
Interacting Proteins
- ANXA11
- DAPK1
- DCTN2
- HEBP2
- KDR
- PDCD6IP
- PEF1
- PLSCR3
- PTPN23
- SEC31A
Pathways
- Cell Death
- Programmed Cell Death
- Transport
- Localization
- Cell Cycle
- Cell Proliferation
- Cell Growth
- Cell Migration
- Induction Of Apoptosis
- Endocytosis
- Cell Cycle Phase
- Tube Formation
- Proteolysis
PTMs
- Phosphorylation
- Cleavage
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/PDCD6
bosterbio.com/bosterbio-gene-info-cards/PDCD6
References
PMID: 11278427 by Kitaura Y., et al. Peflin and ALG-2, members of the penta-EF-hand protein family, form a heterodimer that dissociates in a Ca2+-dependent manner.
PMID: 11883899 by Kitaura Y., et al. Both ALG-2 and peflin, penta-EF-hand (PEF) proteins, are stabilized by dimerization through their fifth EF-hand regions.