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Pcsk4 Antibodies
AND Pcsk4 ELISA kits, Pcsk4 Proteins
Many biological assays use antibodies to detect Pcsk4, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Pcsk4 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Pcsk4 antibodies...
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Pcsk4 Infographic by Boster Bio
All Pcsk4 Products
Product
Figures
Specificity
Applications
Price
Mouse, Rat
WB
$370
Cat # PA2086
100 μg/vial
Cat # PA2086
100 μg/vial
Human
$960
Cat # LS054760
100 µg
Cat # LS054760
100 µg
Pcsk4 Overview
Facts about Proprotein convertase subtilisin/kexin type 4.
Proprotein convertase subtilisin/kexin type 4 (Pcsk4)
Proprotein convertase involved in the processing of hormone and other protein precursors at sites comprised of pairs of basic amino acid residues. In men, important for ADAM2 processing in addition to other acrosomal proteins with functions in fertilization and critical for normal fertilization events like sperm capacitation, acrosome reaction and binding of sperm to zona pellucida (PubMed:9192653, PubMed:16371590, PubMed:19342015, PubMed:21302280).
Plays also a role in female fertility, involved in the regulation of trophoblast migration and placental development, may be through the proteolytical processing and activation of proteins like IGF2 (By similarity). May also participate in folliculogenesis from the uterus (PubMed:11164898).
Gene Information
| Mouse | |
|---|---|
| Gene Name: | Pcsk4 |
| Uniprot: | P29121 |
| Entrez: | 18551 |
Family
| Belongs to: |
|---|
| peptidase S8 family |
Alternative Names
DKFZp434B217; EC 3.4.21; EC 3.4.21.75; EC 3.4.21.93; MGC34749; PC4EC 3.4.21.-; Proprotein convertase 4; proprotein convertase subtilisin/kexin type 4; SPC5
Molecular Weight
Mass (kDA):
73.214 kDA
Genomic Context
| Mouse | |
|---|---|
| Location: | 10 C1|10 39.72 cM |
| Sequence: | 10; |
Tissue Specificity
Expressed abundantly in the testis since postnatal Day 16 (PubMed:1372895, PubMed:16371590, PubMed:21302280). In testis, strongly detected in round and elongated spermatids as well as spermatocytes. Also observed in residual bodies engulfed by Sertoli cells at spermatogenic stages VIII and IX (PubMed:16371590). In ovaries, expressed in macrophage-like cells of the ovarian theca, interstitium and corpora lutea (PubMed:11164898).
Diseases
- Pituitary Diseases
- Male Infertility
- Vaccinia
- Lyme Disease
- Overlying Behavior
- Subfertility
- Infertility
- Neoplasms
- Tetanus
- Hepatitis
- Pleural Neoplasms
- Endometrial Polyp
Pathways
- Fertilization
- Acrosome Reaction
- Localization
- Spermatogenesis
- Trophoblast Cell Migration
- Transport
- Hyperphosphorylation
- Cell Activation
- Cell Migration
- Proteolysis
- Developmental Maturation
- Macrophage Activation
- Decidualization
PTMs
- Cleavage
- Phosphorylation
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/Pcsk4
bosterbio.com/bosterbio-gene-info-cards/Pcsk4
References
PMID: 1372895 by Nakayama K., et al. Identification of the fourth member of the mammalian endoprotease family homologous to the yeast Kex2 protease. Its testis-specific expression.
PMID: 1448111 by Seidah N.G., et al. Testicular expression of PC4 in the rat: molecular diversity of a novel germ cell-specific Kex2/subtilisin-like proprotein convertase.