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PAFAH1B1 Antibodies
AND PAFAH1B1 ELISA kits, PAFAH1B1 Proteins
Many biological assays use antibodies to detect PAFAH1B1, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with PAFAH1B1 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop PAFAH1B1 antibodies...
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PAFAH1B1 Infographic by Boster Bio
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PAFAH1B1 Overview
Facts about Platelet-activating factor acetylhydrolase IB subunit alpha.
Platelet-activating factor acetylhydrolase IB subunit alpha (PAFAH1B1)
Required for proper activation of Rho GTPases and actin polymerization at the leading edge of locomoting cerebellar neurons and postmigratory hippocampal neurons in response to calcium influx triggered via NMDA receptors. Non-catalytic subunit of an acetylhydrolase complicated which inactivates platelet- activating factor (PAF) by removing the acetyl group in the SN-2 position (By similarity).
Positively regulates the activity of this minus-end directed microtubule motor protein dynein. May improve dynein-mediated microtubule sliding by targeting dynein to the microtubule plus end.
Gene Information
| Human | |
|---|---|
| Gene Name: | PAFAH1B1 |
| Uniprot: | P43034 |
| Entrez: | 5048 |
Family
| Belongs to: |
|---|
| WD repeat LIS1/nudF family |
Alternative Names
LIS-1; LIS1PAF-AH alpha; LIS2; lissencephaly 1 protein; Lissencephaly-1 protein; MDCR; MDS; Miller-Dieker syndrome chromosome region; PAF acetylhydrolase 45 kDa subunit; PAF-AH 45 kDa subunit; PAFAH alpha; PAFAH; PAFAHA; platelet-activating factor acetylhydrolase 1b, regulatory subunit 1 (45kDa); platelet-activating factor acetylhydrolase IB subunit alpha; platelet-activating factor acetylhydrolase, isoform Ib, alpha subunit (45kD); platelet-activating factor acetylhydrolase, isoform Ib, alpha subunit 45kDa; platelet-activating factor acetylhydrolase, isoform Ib, subunit 1 (45kDa)
Molecular Weight
Mass (kDA):
46.638 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 17p13.3 |
| Sequence: | 17; NC_000017.11 (2593210..2685617) |
Tissue Specificity
Fairly ubiquitous expression in both the frontal and occipital areas of the brain.
Subcellular Localizations
Cytoplasm, cytoskeleton. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, spindle. Nucleus membrane. Redistributes to axons during neuronal development. Also localizes to the microtubules of the manchette in elongating spermatids and to the meiotic spindle in spermatocytes (By similarity). Localizes to the plus end of microtubules and to the centrosome. May localize to the nuclear membrane.
Diseases
- Lissencephaly
- Miller Dieker Syndrome
- Classical Lissencephaly
- Congenital Anomaly Of Brain
- Ectopic Tissue
- Subcortical Band Heterotopia
- Classical Lissencephalies And Subcortical Band Heterotopias
- Epilepsy
- Neuronal Migration Disorders
- Brain Diseases
- Congenital Neurologic Anomalies
- Lissencephaly I
Interacting Proteins
- HSP90AA1
- Nde1
- NDEL1
- NUDCD2
- NUDCD3
Pathways
- Brain Development
- Transport
- Localization
- Nuclear Migration
- Cell Migration
- Pathogenesis
- Mitosis
- Cell Division
- Neurogenesis
- Cell Proliferation
- Rna Interference
- Metaphase
- Spermatogenesis
PTMs
- Phosphorylation
- Cleavage
- Deacetylation
Research Areas
- Cell Cycle and Replication
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/PAFAH1B1
bosterbio.com/bosterbio-gene-info-cards/PAFAH1B1
References
PMID: 8355785 by Reiner O., et al. Isolation of a Miller-Dieker lissencephaly gene containing G protein beta-subunit-like repeats.
PMID: 9063735 by Lo Nigro C., et al. Point mutations and an intragenic deletion in LIS1, the lissencephaly causative gene in isolated lissencephaly sequence and Miller-Dieker syndrome.