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Securin Antibodies
AND PTTG1 ELISA kits, Securin Proteins
Many biological assays use antibodies to detect Securin, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Securin in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Securin antibodies...
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PTTG1 Infographic by Boster Bio
All PTTG1 Products
Product
Figures
Specificity
Applications
Price
Anti-Securin Monoclonal Antibody
1 Citations 8 Q&As
Human
Flow Cytometry, IP, IF, IHC, ICC, WB
$370
Cat # M02099
100 μl
Cat # M02099
100 μl
Human
ELISA
$480
Cat # EKC1666
1 kit, containing one 96-well plate and all necessary reagents
Cat # EKC1666
1 kit, containing one 96-well plate and all necessary reagents
PTTG1 Overview
Facts about Securin.
Securin (PTTG1)
Regulatory protein, which plays a central role in chromosome stability, in the p53/TP53 pathway, and DNA repair. Probably acts by blocking the action of important proteins.
Throughout the mitosis, it blocks Separase/ESPL1 function, preventing the proteolysis of the cohesin complex and the subsequent segregation of the chromosomes. At the onset of anaphase, it's ubiquitinated, conducting to its destruction and to the liberation of ESPL1.
Gene Information
| Human | |
|---|---|
| Gene Name: | PTTG1 |
| Uniprot: | O95997 |
| Entrez: | 9232 |
Family
| Belongs to: |
|---|
| securin family |
Alternative Names
EAP1MGC126883; ESP1-associated protein 1; Esp1-associated protein; hPTTG; pituitary tumor-transforming 1; Pituitary tumor-transforming gene 1 protein; PTTGMGC138276; securin; Tumor-transforming protein 1; TUTR1HPTTG
Molecular Weight
Mass (kDA):
22.024 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 5q33.3 |
| Sequence: | 5; NC_000005.10 (160421855..160428744) |
Tissue Specificity
Expressed at low level in most tissues, except in adult testis, where it is highly expressed. Overexpressed in many patients suffering from pituitary adenomas, primary epithelial neoplasias, and esophageal cancer.
Subcellular Localizations
Cytoplasm. Nucleus.
Diseases
- Neoplasms
- Pituitary Diseases
- Malignant Neoplasms
- Pituitary Neoplasms
- Cell Transformation, Neoplastic
- Carcinoma
- Neoplasm Metastasis
- Malignant Paraganglionic Neoplasm
- Malignant Neoplasm Of Breast
- Mammary Neoplasms
- Tumor Angiogenesis
- Liver Carcinoma
- Adenoma
Pathways
- Cell Proliferation
- Cell Cycle
- Pathogenesis
- Mitosis
- Cell Growth
- Angiogenesis
- Secretion
- Cell Division
- Senescence
- Oncogenesis
- Dna Repair
- Chromosome Segregation
- Reverse Transcription
PTMs
- Phosphorylation
Research Areas
- Breast Cancer
- Cell Cycle and Replication
- Mitotic Regulators
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/PTTG1
bosterbio.com/bosterbio-gene-info-cards/PTTG1
References
PMID: 9811450 by Dominguez A., et al. hPTTG, a human homologue of rat PTTG, is overexpressed in hematopoietic neoplasms. Evidence for a transcriptional activation function of hPTTG.
PMID: 10393434 by Kakar S.S., et al. Molecular cloning and characterization of the tumor transforming gene (TUTR1): a novel gene in human tumorigenesis.
2 Publications of Boster Securin Antibodies & ELISA Kits
- PubMed ID: 34081985, Liu XM,Chen F,Wang L,Zhang F,Huo LJ.Checkpoint kinases are required for oocyte m...
- PubMed ID: 24879625, Zhang E, Liu S, Xu Z, Huang S, Tan X, Sun C, Lu L. Tumour Biol. 2014 Sep;35(9):8...
*More publications can be found for each product on its corresponding product page