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- Table of Contents
Facts about Receptor-type tyrosine-protein phosphatase U.
May function in cell proliferation and migration and play a part in the maintenance of epithelial integrity. May play a role in megakaryocytopoiesis.
Human | |
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Gene Name: | PTPRU |
Uniprot: | Q92729 |
Entrez: | 10076 |
Belongs to: |
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protein-tyrosine phosphatase family |
FMI; GLEPP1; hPTP-J; pancreatic carcinoma phosphatase 2; PCP2; PCP-2; pi R-PTP-Psi; protein tyrosine phosphatase J; protein tyrosine phosphatase, receptor type, U; protein-tyrosine phosphatase J; protein-tyrosine phosphatase pi; PTP pi; PTP; PTP-J; PTP-PI; PTPPSI; PTPRO; PTP-RO; PTPRU; Receptor protein tyrosine phosphatase hPTP-J; R-PTP-PSI; R-PTP-U
Mass (kDA):
162.423 kDA
Human | |
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Location: | 1p35.3 |
Sequence: | 1; NC_000001.11 (29236522..29326802) |
High levels in brain, pancreas, and skeletal muscle; less in colon, kidney, liver, stomach, and uterus; not expressed in placenta and spleen. Also detected in heart, prostate, lung, thymus, testis and ovary. Ubiquitously expressed in brain. Expressed by hematopoietic stem cells.
Cell junction. Cell membrane; Single-pass type I membrane protein.
PMID: 8870675 by Crossland S., et al. Molecular cloning and characterization of PTP pi, a novel receptor- like protein-tyrosine phosphatase.
PMID: 8700514 by Wang H.-Y., et al. Characterization of PCP-2, a novel receptor protein tyrosine phosphatase of the MAM domain family.