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PTPRN2 Antibodies
AND PTPRN2 ELISA kits, PTPRN2 Proteins
Many biological assays use antibodies to detect PTPRN2, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with PTPRN2 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop PTPRN2 antibodies...
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PTPRN2 Overview
Facts about Receptor-type tyrosine-protein phosphatase N2.
Receptor-type tyrosine-protein phosphatase N2 (PTPRN2)
Required for the accumulation of normal levels of insulin-containing vesicles and preventing their degradation. Plays a role in insulin secretion in response to glucose stimuli.
Required for normal accumulation of the neurotransmitters norepinephrine, dopamine and serotonin in the brain. In females, but not in males, required for normal accumulation and secretion of pituitary hormones, such as luteinizing hormone (LH) and follicle-stimulating hormone (FSH) (By similarity).
Gene Information
| Human | |
|---|---|
| Gene Name: | PTPRN2 |
| Uniprot: | Q92932 |
| Entrez: | 5799 |
Family
| Belongs to: |
|---|
| protein-tyrosine phosphatase family |
Alternative Names
EC 3.1.3.48; IA-2beta; IAR/receptor-like protein-tyrosine phosphatase; ICAARIARPTPRP; Islet cell autoantigen-related protein; KIAA0387; phogrin; protein tyrosine phosphatase receptor pi; protein tyrosine phosphatase, receptor type, N polypeptide 2; receptor-type tyrosine-protein phosphatase N2; R-PTP-N2; tyrosine phosphatase IA-2 beta
Molecular Weight
Mass (kDA):
111.271 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 7q36.3 |
| Sequence: | 7; NC_000007.14 (157539052..158587823, complement) |
Tissue Specificity
Highest levels in brain and pancreas (PubMed:8954911, PubMed:8798755). Lower levels in trachea, prostate, stomach and spinal chord (PubMed:8798755).
Subcellular Localizations
Cytoplasmic vesicle, secretory vesicle membrane; Single-pass type I membrane protein. Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane; Single-pass type I membrane protein. Predominantly found on dense-core secretory granules. Sorting to secretory granules in part is dependent of the N-terminal propeptide domain of the precursor and its interaction with CPE (By similarity). Transiently found at the cell membrane, when secretory vesicles fuse with the cell membrane to release their cargo. Is then endocytosed and recycled to secretory vesicles involving clathrin-dependent AP2-me
Diseases
- Diabetes Mellitus, Insulin-dependent
- Diabetes Mellitus
- Posttransfusion Purpura
- Autoimmunity
- Insulinoma
- Autoimmune Reaction
- Diabetes, Autoimmune
- Pancreatic Neoplasm
- Neoplasms
- Pituitary Diseases
- Carcinoma
- Malignant Neoplasms
- Prediabetes Syndrome
Pathways
- Secretion
- Exocytosis
- Insulin Secretion
- Localization
- Secretory Pathway
- Endocytosis
- Immune Response
- Pathogenesis
- Transport
- Proteolysis
- Regulated Secretory Pathway
- Dna Methylation
- Methylation
PTMs
- Methylation
- Phosphorylation
- Biotinylation
Research Areas
- Lipid and Metabolism
- Protein Phosphatase
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/PTPRN2
bosterbio.com/bosterbio-gene-info-cards/PTPRN2
References
PMID: 8878534 by Kawasaki E., et al. Molecular cloning and characterization of the human transmembrane protein tyrosine phosphatase homologue, phogrin, an autoantigen of type 1 diabetes.
PMID: 8954911 by Smith P.D., et al. ICAAR, a novel member of a new family of transmembrane, tyrosine phosphatase-like proteins.