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PTPRJ Antibodies
AND PTPRJ ELISA kits, PTPRJ Proteins
Many biological assays use antibodies to detect PTPRJ, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with PTPRJ in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop PTPRJ antibodies...
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PTPRJ Infographic by Boster Bio
All PTPRJ Products
Product
Figures
Specificity
Applications
Price
Anti-PTPRJ/Dep1 Antibody
5 Q&As
Human, Mouse, Rat
ELISA, IHC-P, WB, IF (paraffin)
$335
Cat # A02319-1
100ul
Cat # A02319-1
100ul
Human, Rat
ELISA, Flow Cytometry, IF, IHC, WB
$370
Cat # A02319-2
100 μg/vial
Cat # A02319-2
100 μg/vial
PTPRJ Overview
Facts about Receptor-type tyrosine-protein phosphatase eta.
Receptor-type tyrosine-protein phosphatase eta (PTPRJ)
Tyrosine phosphatase That dephosphorylates or Leads to the dephosphorylation of CTNND1, FLT3, PDGFRB, MET, RET (variant MEN2A), KDR, LYN, SRC, MAPK1, MAPK3, EGFR, TJP1, OCLN, PIK3R1 and PIK3R2.
Involved in vascular development.Positively affects cell-matrix adhesion. Positive regulator of platelet activation and thrombosis.
Gene Information
| Human | |
|---|---|
| Gene Name: | PTPRJ |
| Uniprot: | Q12913 |
| Entrez: | 5795 |
Family
| Belongs to: |
|---|
| protein-tyrosine phosphatase family |
Alternative Names
CD148 antigen; CD148; Density-enhanced phosphatase 1; DEP1; DEP-1; DEP1EC 3.1.3.48; HPTP eta; HPTPeta; HPTP-eta; human density enhanced phosphatase-1; protein tyrosine phosphatase, receptor type, J polypeptide; protein tyrosine phosphatase, receptor type, J; Protein-tyrosine phosphatase eta; Protein-tyrosine phosphatase receptor type J; PTPRJ; receptor-type tyrosine-protein phosphatase eta; R-PTP-ETA; R-PTP-J; SCC1; susceptibility to colon cancer 1, mouse, homolog of
Molecular Weight
Mass (kDA):
145.941 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 11p11.2 |
| Sequence: | 11; NC_000011.10 (47980504..48170839) |
Tissue Specificity
Expressed in the promyelocytic cell line HL- 60, the granulocyte-macrophage colony-stimulating factor-dependent leukemic cell line F-36P, and the IL3 and erythropoietin-dependent leukemic cell line F-36E. Expressed predominantly in epithelial cells and lymphocytes. Enhanced expression at high cell density.
Subcellular Localizations
Cell membrane; Single-pass type I membrane protein. Cell projection, ruffle membrane. Cell junction. After T-cell stimulation, it is temporarily excluded from immunological synapses.
Diseases
- Neoplasms
- Malignant Neoplasms
- Posttransfusion Purpura
- Tissue Adhesions
- Carcinoma
- Cell Transformation, Neoplastic
- Malignant Paraganglionic Neoplasm
- Malignant Tumor Of Colon
- Thyroid Neoplasm
- Mammary Neoplasms
- Colorectal Neoplasms
- Leukemia
- Colorectal Cancer
Interacting Proteins
- CTNNB1
- CTNND1
- ERBB2
- FLT1
- FLT3
- GAB1
- GHR
- KDR
- MAPK1
- MAPK3
Pathways
- Cell Growth
- Cell Proliferation
- Cell Activation
- T Cell Activation
- Cell Migration
- Contact Inhibition
- Localization
- Platelet Activation
- Cell Differentiation
- Chemotaxis
- Cell Adhesion
- Hyperphosphorylation
- Phagocytosis
PTMs
- Phosphorylation
- Dephosphorylation
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/PTPRJ
bosterbio.com/bosterbio-gene-info-cards/PTPRJ
References
PMID: 7937872 by Oestman A., et al. Expression of DEP-1, a receptor-like protein-tyrosine-phosphatase, is enhanced with increasing cell density.
PMID: 7994032 by Honda H., et al. Molecular cloning, characterization, and chromosomal localization of a novel protein-tyrosine phosphatase, HPTP eta.