PTPN2 Antibodies

AND PTPN2 ELISA kits, PTPN2 Proteins

Many biological assays use antibodies to detect PTPN2, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with PTPN2 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop PTPN2 antibodies...

We validate the specificity of these antibodies to PTPN2 by testing them on tissues known to express PTPN2 positively and negatively. Browse below to find the PTPN2 antibody that suites your experiment. We have 5 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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PTPN2 Infographic by Boster Bio

All PTPN2 Products

Filter by Application:

Product

Figures

Specificity

Applications

Price

Anti-TCPTP/PTPN2 Antibody Picoband®

1 Q&As

Human, Rat

IF, IHC, ICC, WB

$370
Cat # PB9501
100 μg/vial

Anti-PTN2 PTPN2 Antibody

Human, Mouse, Rat

ELISA, WB

$380
Cat # A01597
100ul

Anti-TCPTP/PTPN2 Antibody Picoband®

Human

ELISA, Flow Cytometry, WB

$370
Cat # A01597-1
100 μg/vial

Anti-PTPN2 Rabbit Monoclonal Antibody

Human, Mouse

Flow Cytometry, IP, WB

$370
Cat # M01597
100 μl/vial

TCPTP (PTPN2) (NM_002828) Human Over-expression Lysate

Human

$628
Cat # LS005771
100 µg

PTPN2 Overview

Facts about Tyrosine-protein phosphatase non-receptor type 2.

PTPN2 3D structure. Source: alphafold

Tyrosine-protein phosphatase non-receptor type 2 (PTPN2)

Non-receptor type tyrosine-specific phosphatase which dephosphorylates receptor protein tyrosine kinases including INSR, EGFR, CSF1R, PDGFR. Additionally dephosphorylates non-receptor protein tyrosine kinases like JAK1, JAK2, JAK3, Src family kinases, STAT1, STAT3 and STAT6 either in the nucleus or the cytoplasm.

Plays a multifaceted and important role in the maturation of the immune system. Functions in T-cell receptor signaling through dephosphorylation of FYN and LCK to control T-cells differentiation and activation.

Gene Information

Human
Gene Name:	PTPN2
Uniprot:	P17706
Entrez:	5771

Family

Belongs to:

protein-tyrosine phosphatase family

Alternative Names

protein tyrosine phosphatase, non-receptor type 2; PTP2; PTPN2; PTPTPTN2; T-cell protein tyrosine phosphatase; T-cell protein-tyrosine phosphatase; TCELLPTP; TCPTP; TC-PTP; TCPTPEC 3.1.3.48; tyrosine-protein phosphatase non-receptor type 2

Molecular Weight

Mass (kDA):
48.473 kDA

Genomic Context


Human

Location:	18p11.21
Sequence:	18; NC_000018.10 (12785478..12884351, complement)

Tissue Specificity

Ubiquitously expressed. Isoform 2 is probably the major isoform. Isoform 1 is expressed in T-cells and in placenta.

Subcellular Localizations

[Isoform 1]: Endoplasmic reticulum. Endoplasmic reticulum-Golgi intermediate compartment. Targeted to the endoplasmic reticulum by its C-terminal hydrophobic region.; [Isoform 2]: Nucleus. Cytoplasm. Cell membrane. Predominantly localizes to chromatin (By similarity). Able to shuttle between the nucleus and the cytoplasm and to dephosphorylate plasma membrane receptors (PubMed:9488479). Recruited by activated ITGA1 at the plasma membrane.