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PTPN1 Antibodies
AND PTPN1 ELISA kits, PTPN1 Proteins
Many biological assays use antibodies to detect PTPN1, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with PTPN1 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop PTPN1 antibodies...
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PTPN1 Infographic by Boster Bio
All PTPN1 Products
Product
Figures
Specificity
Applications
Price
Anti-PTP1B/PTPN1 Antibody Picoband®
1 Citations
Human, Mouse, Rat
Flow Cytometry, IF, IHC, IHC-F, WB
$370
Cat # A00613-1
100 μg/vial
Cat # A00613-1
100 μg/vial
Human
Flow Cytometry, IF, IHC, ICC, WB
$370
Cat # M00613
100 μl
Cat # M00613
100 μl
Human
Flow Cytometry
$515
Cat # A00613-Dyl488
100 μg/vial
Cat # A00613-Dyl488
100 μg/vial
Human
Flow Cytometry
$515
Cat # A00613-Dyl550
100 μg/vial
Cat # A00613-Dyl550
100 μg/vial
Human, Mouse, Rat
ELISA
$480
Cat # EKC1489
1 kit, containing one 96-well plate and all necessary reagents
Cat # EKC1489
1 kit, containing one 96-well plate and all necessary reagents
Human, Mouse, Rat
ELISA
$540
Cat # EKC2208
1 kit, containing two 96-well plates and all necessary reagents
Cat # EKC2208
1 kit, containing two 96-well plates and all necessary reagents
Human, Monkey, Mouse, Rat
ELISA, IHC, WB
$380
Cat # A00613S50
100ul
Cat # A00613S50
100ul
Dog, Human, Monkey, Rat
Flow Cytometry, IF, IHC, WB
$523
Cat # M00613-1
100 µl
Cat # M00613-1
100 µl
PTPN1 Overview
Facts about Tyrosine-protein phosphatase non-receptor type 1.
Tyrosine-protein phosphatase non-receptor type 1 (PTPN1)
Tyrosine-protein phosphatase which functions as a regulator of endoplasmic reticulum unfolded protein response. Mediates dephosphorylation of EIF2AK3/PERK; inactivating the protein kinase activity of EIF2AK3/PERK.
May play an important role in CKII- and p60c-src-induced signal transduction cascades. May regulate the EFNA5-EPHA3 signaling pathway which modulates cell reorganization and cell-cell repulsion.
Gene Information
| Human | |
|---|---|
| Gene Name: | PTPN1 |
| Uniprot: | P18031 |
| Entrez: | 5770 |
Family
| Belongs to: |
|---|
| protein-tyrosine phosphatase family |
Alternative Names
EC 3.1.3.48; protein tyrosine phosphatase 1B; protein tyrosine phosphatase, non-receptor type 1; Protein-tyrosine phosphatase 1B; PTP1B; PTP-1B; PTP1Bprotein tyrosine phosphatase, placental; PTPN1; tyrosine-protein phosphatase non-receptor type 1
Molecular Weight
Mass (kDA):
49.967 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 20q13.13 |
| Sequence: | 20; NC_000020.11 (50510321..50585241) |
Subcellular Localizations
Endoplasmic reticulum membrane; Peripheral membrane protein; Cytoplasmic side. Interacts with EPHA3 at the cell membrane.
Diseases
- Diabetes Mellitus
- Obesity
- Diabetes Mellitus, Non-insulin-dependent
- Insulin Resistance
- Posttransfusion Purpura
- Insulin Sensitivity
- Malignant Neoplasms
- Neoplasms
- Tissue Adhesions
- Impaired Glucose Tolerance
- Hyperglycemia
- Inflammation
- Malignant Neoplasm Of Breast
Interacting Proteins
- BCAR1
- Bcar1
- Bcar1
- CAPN1
- CAV1
- Cdh2
- Crk
- CTTN
- EGFR
- EPOR
Pathways
- Glucose Homeostasis
- Pathogenesis
- Localization
- Secretion
- Cell Proliferation
- Transport
- Cell Cycle
- Glucose Transport
- Insulin Secretion
- Cell Adhesion
- Aging
- Cell Growth
- Rna Interference
PTMs
- Phosphorylation
- Dephosphorylation
- Oxidation
- Cleavage
- Glutathionylation
- Carboxylation
- Nitrosylation
- Prenylation
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/PTPN1
bosterbio.com/bosterbio-gene-info-cards/PTPN1
References
PMID: 2157211 by Chernoff J., et al. Cloning of a cDNA for a major human protein-tyrosine-phosphatase.
PMID: 2164224 by Brown-Shimer S., et al. Molecular cloning and chromosome mapping of the human gene encoding protein phosphotyrosyl phosphatase 1B.
1 Publications of Boster PTPN1 Antibodies & ELISA Kits
- PubMed ID: 10.2147/DDDT.S265198, Integrated Network Pharmacology Analysis and Experimental Validation to Reveal t...
*More publications can be found for each product on its corresponding product page