PTPN1 Antibodies

Tyrosine-protein phosphatase non-receptor type 1 (PTPN1)

Tyrosine-protein phosphatase which functions as a regulator of endoplasmic reticulum unfolded protein response. Mediates dephosphorylation of EIF2AK3/PERK; inactivating the protein kinase activity of EIF2AK3/PERK.

May play an important role in CKII- and p60c-src-induced signal transduction cascades. May regulate the EFNA5-EPHA3 signaling pathway which modulates cell reorganization and cell-cell repulsion.

Gene Information

Human
Gene Name:	PTPN1
Uniprot:	P18031
Entrez:	5770

Family

Belongs to:
protein-tyrosine phosphatase family

Alternative Names

EC 3.1.3.48; protein tyrosine phosphatase 1B; protein tyrosine phosphatase, non-receptor type 1; Protein-tyrosine phosphatase 1B; PTP1B; PTP-1B; PTP1Bprotein tyrosine phosphatase, placental; PTPN1; tyrosine-protein phosphatase non-receptor type 1

Molecular Weight

Mass (kDA):
49.967 kDA

Genomic Context

Human
Location:	20q13.13
Sequence:	20; NC_000020.11 (50510321..50585241)

Subcellular Localizations

Endoplasmic reticulum membrane; Peripheral membrane protein; Cytoplasmic side. Interacts with EPHA3 at the cell membrane.

Diseases

• Diabetes Mellitus
• Obesity
• Diabetes Mellitus, Non-insulin-dependent
• Insulin Resistance
• Posttransfusion Purpura
• Insulin Sensitivity
• Malignant Neoplasms
• Neoplasms
• Tissue Adhesions
• Impaired Glucose Tolerance
• Hyperglycemia
• Inflammation
• Malignant Neoplasm Of Breast

• Cell Transformation, Neoplastic
• Hyperinsulinism
• Mammary Neoplasms
• Diabetes Mellitus, Experimental
• Carcinoma
• Hypertensive Disease
• Dyslipidemias

Interacting Proteins

• BCAR1
• Bcar1
• Bcar1
• CAPN1
• CAV1

• Cdh2
• Crk
• CTTN
• EGFR
• EPOR

• GHR
• GRB2
• Grb2
• IGF1R
• INSR

• Irs1
• ITGB1
• ITGB3
• JAK2
• LAT

• MET
• NTRK1
• PDGFRB
• Pdgfrb
• Plcg1

• Ptk2
• Pxn
• RMDN3
• ROS1
• SRC

• STAT3
• STAT5A
• Sumo1
• TRPV6
• TXN

Pathways

• Glucose Homeostasis
• Pathogenesis
• Localization
• Secretion
• Cell Proliferation
• Transport
• Cell Cycle
• Glucose Transport
• Insulin Secretion
• Cell Adhesion
• Aging
• Cell Growth
• Rna Interference

• Cell Migration
• Cell Motility
• Cell-cell Adhesion
• Bioluminescence
• Platelet Aggregation
• Sensitization
• Dna Amplification

PTMs

• Phosphorylation
• Dephosphorylation
• Oxidation
• Cleavage
• Glutathionylation
• Carboxylation
• Nitrosylation
• Prenylation

• Reduction
• Sumoylation
• Phosphorothioation
• Decarboxylation
• Deglutathionylation
• Ubiquitination
• Methylation
• Myristoylation

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/PTPN1

Best Uses Of The PTPN1 Marker

The marker for the PTPN1 protein is a protein that is found in the central nervous system. Antibodies to this protein are believed to have high specificity and affinity. Boster Bio antibodies were tested on various platforms, including positive and negative samples. Moreover, Boster rewards the scientists who examine the products early and provide credits for the product. The rewards are accessible to all scientists around the world.

Boster Bio Anti-VDAC/Porin/VDAC1 Antibody

The Boster Bio Anti-VDAC/PORIN/VDAC1 antibody has been validated in IHC and WB applications. This antibody reacts with Human, Mouse, and Rat. It is extremely specific and comes at a low price. The product has been tested on a variety of platforms and is available for purchase via the Boster Bio website. Boster's Customer Service confirms the product is compatible.

The LP3 protein is made from VDAC1, which represents the sequence of the loop that is facing the cell's cytosol. It exhibits a lower binding affinity to mutant SOD1 than the (1-26)-N-terminal peptide. This indicates that the VDAC1 peptide is specific for mutant SOD1G93A and SOD1G85R.

The mitochondria's outer membrane contains a major component, the voltage-dependent anion channel proteins. They facilitate the exchange of metabolites and play a role in regulating different functions. They are crucial for metabolism and regulates the apoptosis process. Multiple pseudogenes of this gene have been discovered on chromosomes 1, 2, 3 6, 9, 12, X, and Y.

This antibody is targeted to misfolded SOD1 proteins. In the laboratory, this antibody is effective in detecting the misfolded SOD1 protein. The peptides are able to be used to detect flow cytometry or immunofluorescence to observe the co-localization between the proteins. These results were observed with both transfected cells aswell with the human mutant SOD1G93A.

Another key feature of VDAC/Porin/VDAC1 antibodies is their ability to induce apoptosis in cancer cells. This antibody is ideal for research studies as well as clinical trials. It can be purchased through Boster Bio. There are no restrictions on its use in humans. In fact, it has already been approved to be used in cancer therapy.

The N-terminal peptide of VDAC1 blocks the function of mutant SOD1 in motor neurons. The peptides in VDAC1 connect to mutant SOD1 to increase cell survival. Further research is required to determine the exact function of VDAC3 in humans. A study of human microglia cells could be required to determine if VDAC3 is functional in these types of cells.

Boster Bio Anti-Synaptophysin SYP Rabbit Monoclonal Antibody

The Synaptophysin SYP is a membrane protein that's integral to synaptic vesicles. It is found throughout the central nervous system in neurons. It is a crucial element of synaptic plasticity and is used to identify synaptic protein. It also plays a role in synaptogenesis, the process through which synaptic neurotransmitters develop and released from synaptic vessels. It may also play a part in vesicle structure and targeting. It is a multi-pass membrane protein.

Vaccination with PCV2 helps to prevent viremia in breeding age animals. Vertical transmission cannot be prevented by vaccination. Vaccination can prevent future generations from being exposed to PCV2. In addition to protecting against infection, this antibody can help in monitoring the severity of disease.

The M1 gene is an ORF that encodes for a small protein with arginine residues. Its sequence is similar to the hemorrhagic septicemia viral virus. It is a significant viral pathogen in Japanese flounder. It has genes for M1 as well as M2. The M1 gene comprises seven hundred and seventy three nucleotide long proteins that encode the carboxyl-terminal portion of a protein that contains 250 amino acids.

In a patient who was symptomatic with multiple myeloma and IgA-lambda-type M-protein was found in his peripheral blood stem cells. The M-protein concentration was 6100 and 23 mg/dl. Electrophoresis of the serum protein confirmed that he also had IgA2-lambda-type M-protein. Western blotting confirmed the presence of the IgA2-lambda type of M-protein.

The Boster Bio Anti-Synaptomesin SYP Rabbit Monocloclonal Immunoglobulin (RMA) is a monoclonal antibody that recognizes a specific synapses-specific protein in the central nervous system. It has been shown that it protects against H9 type avian influenza virus.

The antibody is used to treat autoimmune disorders. It has also been researched for its ability to prevent rejection. It is utilized for post-transplant antirejection therapy. Syngeneic HSCT was employed to determine whether it was tolerogenic for islet allograft survival. It was used in research where BALB/c mice were transplanted into C57BL/6 kidney subcapsular and models of pulmonary metastasis. The HSCT mice had a greater survival rate for islet allografts compared to the mice that were controlled. The mice also showed lower lymphocyte infiltration and stronger staining of insulin than control mice.

Boster Bio Anti-Synaptophysin SYP Antibody

The Boster Bio Antisynaptopsin Synaptopsin SYP Antibody reacts to Rat. It is suitable for storage at -20degC for a year. The Anti-Syp Antibody can be used in experiments using rats and mice. It can be used to detect PTPN1 inside the brain tissue of rats as well as in the ascites fluid of mice.