PTP4A2 Antibodies

Protein tyrosine phosphatase type IVA 2 (PTP4A2)

Protein tyrosine phosphatase which stimulates progression from G1 into S phase during mitosis. Promotes tumors.

Inhibits geranylgeranyl transferase type II action by blocking the association between RABGGTA and RABGGTB. .

Gene Information

Human
Gene Name:	PTP4A2
Uniprot:	Q12974
Entrez:	8073

Family

Belongs to:
protein-tyrosine phosphatase family

Alternative Names

EC 3.1.3.48; HH13; HH7-2; HU-PP-1; HU-PP-1HH13; OV-1; OV-1PTP4A; PRL2; PRL-2; PRL-2HH7-2; PRL2protein tyrosine phosphatase IVA; protein tyrosine phosphatase IVA2; protein tyrosine phosphatase type IVA 2; protein tyrosine phosphatase type IVA, member 2; Protein-tyrosine phosphatase 4a2; Protein-tyrosine phosphatase of regenerating liver 2; PTP(CAAXII); PTP4A2; PTPCAAX2; PTPCAAX2phosphatase of regenerating liver 2; ptp-IV1a; ptp-IV1b

Molecular Weight

Mass (kDA):
19.127 kDA

Genomic Context

Human
Location:	1p35.2
Sequence:	1; NC_000001.11 (31906421..31938368, complement)

Tissue Specificity

Ubiquitously expressed, with highest levels in skeletal muscle, heart and thymus. Overexpressed in prostate tumor tissue.

Subcellular Localizations

Cell membrane. Early endosome. Cytoplasm.

Diseases

• Neoplasm Metastasis
• Neoplasms
• Malignant Neoplasms
• Cell Invasion
• Posttransfusion Purpura
• Neoplasm Invasiveness
• Carcinoma
• Malignant Paraganglionic Neoplasm
• Malignant Neoplasm Of Breast
• Mammary Neoplasms
• Colonic Neoplasms
• Colorectal Cancer
• Cell Transformation, Neoplastic

• Lymphatic Metastasis
• Metastatic Malignant Neoplasm To The Lymph Node
• Myeloid Leukemia
• Adenocarcinoma
• Malignant Neoplasm Of Lung
• Leukemia, Myelocytic, Acute
• Lung Neoplasms

Pathways

• Prenylation
• Cell Proliferation
• Localization
• Cell Migration
• Cell Adhesion
• Pathogenesis
• Histone Modification
• Cell Division
• Cellular Localization
• Cell Motility

• Cell Cycle
• Cell Growth
• Rna Interference
• Tissue Homeostasis
• Chromatin Remodeling

PTMs

• Prenylation
• Farnesylation

• Phosphorylation
• Dephosphorylation

• Geranylgeranylation

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/PTP4A2

Best Uses Of The PTP4A2 Marker

If you're interested in discovering more about Steven Boster and the research He's performed, this article will provide you with an overview of the man behind the work. In addition to His philanthropic work, Boster has won numerous awards and honors for his work. Read on to learn more about this incredibly influential scientist and his work. It's time to stop wondering if you can use his PTP4A2 marker in your research!

His research

The expression of PTP4A2, a member of the protein family known as proto-oncogenes, plays a dual role in tumorigenesis. The protein product interacts with the beta subunit of Rab geranylgeranyltransferase II. His research used TCGA datasets to study the expression of PTP4A2 in hepatoma tissues. Moreover, he found that PTP4A2 expression correlated negatively with the expression of miRNA-130a-5p.

The PTP4A2 gene has an excellent prognostic value as a marker of early-stage breast cancer. Moreover, studies have shown that high PTP4A2 expression is associated with increased overall survival and disease-free survival. Further, it may be a useful target for therapeutics for women suffering from breast cancer. However, the research remains preliminary. This research has been supported by the work of Dr. David Wong.

His philanthropic work

Bill Gates has been phenomenally successful in his commercial career, but that success hasn't stopped him from making a difference in the lives of others through his philanthropic work. While the philanthropist is known for addressing critical issues and promoting innovative ideas, he is equally driven by his desire to improve society. To understand why Gates' philanthropic work is so important, let's look at some of the ways that he has helped other people.

The Egyptian forward has also addressed social, economic, and humanitarian issues. During 2014, more than 7.3 million Egyptians lacked access to clean drinking water and adequate sanitation. In rural areas, lack of sanitation surfaces and infrastructure causes the worst problems. Through his philanthropic work, he has raised awareness and funds for many worthy projects. By supporting these causes, Salah is helping improve the lives of his fellow Egyptians.