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- Table of Contents
Facts about Prostaglandin reductase 1.
Catalyzes the conversion of leukotriene B4 to its biologically less active metabolite, 12-oxo-leukotriene B4. This is an initial and key step of metabolic inactivation of leukotriene B4.
Human | |
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Gene Name: | PTGR1 |
Uniprot: | Q14914 |
Entrez: | 22949 |
Belongs to: |
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NADP-dependent oxidoreductase L4BD family |
15-oxoprostaglandin 13-reductase; EC 1.3.1.-; EC 1.3.1.48; EC 1.3.1.74; FLJ99229; leukotriene B4 12-hydroxydehydrogenase; LTB4DH; MGC34943; NADP-dependent leukotriene B4 12-hydroxydehydrogenase; PGR1; PRG-1; prostaglandin reductase 1; ZADH3; zinc binding alcohol dehydrogenase domain containing 3
Mass (kDA):
35.87 kDA
Human | |
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Location: | 9q31.3 |
Sequence: | 9; NC_000009.12 (111549722..111599855, complement) |
High expression in the kidney, liver, and intestine but not in leukocytes.
Cytoplasm.
PMID: 8576264 by Yokomizo T., et al. cDNA cloning, expression, and mutagenesis study of leukotriene B4 12- hydroxydehydrogenase.