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- Table of Contents
Facts about Protein patched homolog 1.
Appears to have a tumor suppressor function, as inactivation of this protein is most likely a necessary, if not sufficient step for tumorigenesis. .
Human | |
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Gene Name: | PTCH1 |
Uniprot: | Q13635 |
Entrez: | 5727 |
Belongs to: |
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patched family |
BCNS; BCNSFLJ42602; FLJ26746; HPE7; mes; NBCCS; patched (Drosophila) homolog; Patched 1; patched homolog (Drosophila); patched homolog 1 (Drosophila); patched homolog 1; protein patched homolog 1; PTC; ptc1; PTCH protein +12b; PTCH protein +4'; PTCH protein -10; PTCH; PTCH1; PTCH11
Mass (kDA):
160.545 kDA
Human | |
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Location: | 9q22.32 |
Sequence: | 9; NC_000009.12 (95442980..95517057, complement) |
In the adult, expressed in brain, lung, liver, heart, placenta, skeletal muscle, pancreas and kidney. Expressed in tumor cells but not in normal skin.
Cell membrane; Multi-pass membrane protein.
PMID: 8658145 by Johnson R.L., et al. Human homolog of patched, a candidate gene for the basal cell nevus syndrome.
PMID: 8647801 by Hahn H., et al. A mammalian patched homolog is expressed in target tissues of sonic hedgehog and maps to a region associated with developmental abnormalities.