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PSMD10 Antibodies
AND PSMD10 ELISA kits, PSMD10 Proteins
Many biological assays use antibodies to detect PSMD10, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with PSMD10 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop PSMD10 antibodies...
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PSMD10 Infographic by Boster Bio
All PSMD10 Products
Product
Figures
Specificity
Applications
Price
Human, Mouse, Rat
Flow Cytometry, WB
$523
Cat # M03169
100 µl
Cat # M03169
100 µl
PSMD10 Overview
Facts about 26S proteasome non-ATPase regulatory subunit 10.
26S proteasome non-ATPase regulatory subunit 10 (PSMD10)
Acts as a chaperone during the assembly of the 26S proteasome, especially of the PA700/19S regulatory complex (RC). In the first step of the base subcomplex assembly is part of an intermediate PSMD10:PSMC4:PSMC5:PAAF1 module that probably assembles with a PSMD5:PSMC2:PSMC1:PSMD2 module.
Independently of the proteasome, modulates EGF-induced AKT activation through inhibition of the RHOA/ROCK/PTEN pathway, leading to prolonged AKT activation. Plays an important role in RAS-induced tumorigenesis.
Gene Information
| Human | |
|---|---|
| Gene Name: | PSMD10 |
| Uniprot: | O75832 |
| Entrez: | 5716 |
Family
| Belongs to: |
|---|
| No superfamily |
Alternative Names
26S proteasome non-ATPase regulatory subunit 10; 26S proteasome regulatory subunit p28; ankyrin repeat protein; dJ889N15.2; gankyrin; hepatocellular carcinoma-associated protein p28-II; p28; p28(GANK); proteasome (prosome, macropain) 26S subunit, non-ATPase, 10
Molecular Weight
Mass (kDA):
24.428 kDA
Genomic Context
| Human | |
|---|---|
| Location: | Xq22.3 |
| Sequence: | X; NC_000023.11 (108084205..108091644, complement) |
Tissue Specificity
Tends to be up-regulated in cancer cells with RAS mutations, including lung cancers and adenocarconimas (at protein level).
Subcellular Localizations
Cytoplasm. Nucleus.
Diseases
- Carcinoma
- Liver Carcinoma
- Neoplasms
- Malignant Neoplasms
- Retinoblastoma
- Liver Neoplasms
- Cell Transformation, Neoplastic
- Neoplasm Metastasis
- Hepatocarcinogenesis
- Carcinogenesis
- Liver Cirrhosis
- Liver Neoplasms, Experimental
Interacting Proteins
- CLIC1
- GRSF1
- HIF1AN
- HSPA1A
- MAGEA4
- NCK2
- PSMC4
Pathways
- Cell Cycle
- Cell Proliferation
- Liver Regeneration
- Regeneration
- Cell Growth
- Rna Interference
- Hyperphosphorylation
- Nuclear Export
- Hepatocyte Proliferation
- Localization
- Cell Death
- Cell Activation
- Cell Cycle Checkpoint
PTMs
- Phosphorylation
- Ubiquitination
Research Areas
- Cancer
- Cell Biology
- Tumor Suppressors
- Ubiquitin Proteasome Pathway
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/PSMD10
bosterbio.com/bosterbio-gene-info-cards/PSMD10
References
PMID: 9714768 by Hori T., et al. cDNA cloning and functional analysis of p28 (Nas6p) and p40.5 (Nas7p), two novel regulatory subunits of the 26S proteasome.
PMID: 10613832 by Higashitsuji H., et al. Reduced stability of retinoblastoma protein by gankyrin, an oncogenic ankyrin-repeat protein overexpressed in hepatomas.