Proteasome subunit alpha type-1 (PSMA1)

Component of the 20S core proteasome complex involved in the proteolytic degradation of the majority of intracellular proteins. This complex plays a number of essential functions within the cell by connecting with different regulatory contaminants.

Connected with two 19S regulatory particles, forms the 26S proteasome and so participates in the ATP-dependent degradation of ubiquitinated proteins. The 26S proteasome plays an integral role in the maintenance of protein homeostasis by removing misfolded or damaged proteins that could impair cellular capabilities, and by removing proteins whose functions are no longer required.