Presenilin-1 Antibodies

AND PSEN1 ELISA kits, Presenilin-1 Proteins

Many biological assays use antibodies to detect Presenilin-1, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Presenilin-1 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Presenilin-1 antibodies...

We validate the specificity of these antibodies to Presenilin-1 by testing them on tissues known to express PSEN1 positively and negatively. Browse below to find the PSEN1 antibody that suites your experiment. We have 7 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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PSEN1 Infographic by Boster Bio

All PSEN1 Products

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Specificity

Applications

Price

Anti-Presenilin 1 PSEN1 Antibody

Human, Mouse, Rat

IHC, WB

$399
Cat # A00138-1
100μl

Anti-Presenilin 1 Monoclonal Antibody

6 Q&As

Human, Mouse, Rat

Flow Cytometry, WB

$370
Cat # M00138-1
100 μl

PSEN1 Colorimetric Cell-Based ELISA Kit

Human

ELISA

$480
Cat # EKC1487
1 kit, containing one 96-well plate and all necessary reagents

Presenilin 1 Colorimetric Cell-Based ELISA

Human

ELISA

$480
Cat # EKC1612
1 kit, containing one 96-well plate and all necessary reagents

PSEN1 (Phospho-Ser357) Colorimetric Cell-Based ELISA Kit

Human, Mouse, Rat

ELISA

$540
Cat # EKC2622
1 kit, containing two 96-well plates and all necessary reagents

Anti-Phospho-Presenilin 1 (S357) PSEN1 Antibody

Human, Mouse, Rat

ELISA, IHC, WB

$380
Cat # A00138S357
100ul

Anti-Presenilin 1/PS-1/PSEN1 Antibody Picoband®

Human, Mouse, Rat

ELISA, Flow Cytometry, IF, ICC, WB

$370
Cat # A00138-3
100 μg/vial

PSEN1 Overview

Facts about Presenilin-1.

PSEN1 3D structure. Source: alphafold

Presenilin-1 (PSEN1)

Catalytic subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (amyloid-beta precursor protein) (PubMed:15274632, PubMed:10545183, PubMed:10593990, PubMed:10206644, PubMed:10899933, PubMed:10811883, PubMed:12679784, PubMed:12740439, PubMed:25043039, PubMed:26280335). Requires the presence of the other members of the gamma-secretase complex for protease activity (PubMed:15274632, PubMed:25043039, PubMed:26280335).

Plays a role in Notch and Wnt signaling cascades and regulation of downstream processes via its role in processing key regulatory proteins, and by regulating cytosolic CTNNB1 levels (PubMed:9738936, PubMed:10593990, PubMed:10899933, PubMed:10811883). Stimulates cell-cell adhesion through its interaction with CDH1; this stabilizes the complexes between CDH1 (E-cadherin) and its interaction partners CTNNB1 (beta-catenin), CTNND1 and JUP (gamma-catenin) (PubMed:11953314).

Gene Information

Human
Gene Name:	PSEN1
Uniprot:	P49768
Entrez:	5663

Family

Belongs to:

peptidase A22A family

Alternative Names

AD3EC 3.4.23.-; Alzheimer disease 3; EC 3.4.23; FAD; presenilin 1; Presenilin1; Presenilin-1; Protein S182; PS-1; PS1presenilin-1; PSEN1; PSNL1; S182

Molecular Weight

Mass (kDA):
52.668 kDA

Genomic Context


Human

Location:	14q24.2
Sequence:	14; NC_000014.9 (73136436..73223691)

Tissue Specificity

Detected in azurophile granules in neutrophils and in platelet cytoplasmic granules (at protein level) (PubMed:11987239). Expressed in a wide range of tissues including various regions of the brain, liver, spleen and lymph nodes (PubMed:7596406, PubMed:8641442, PubMed:8574969).

Subcellular Localizations

Endoplasmic reticulum. Endoplasmic reticulum membrane; Multi-pass membrane protein. Golgi apparatus membrane; Multi-pass membrane protein. Cytoplasmic granule. Cell membrane; Multi-pass membrane protein. Cell projection, growth cone. Early endosome. Early endosome membrane; Multi-pass membrane protein. Cell projection, neuron projection. Cell projection, axon. Cell junction, synapse. Translocates with bound NOTCH1 from the endoplasmic reticulum and/or Golgi to the cell surface (PubMed:10593990). Colocalizes with CDH1/2 at sites of cell-cell contact. Colocalizes with CTNNB1 in the endoplasmic r